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Free Radicals: from Basic Science to Medicine pp 349–363Cite as

An in Vitro Approach to the Study of Inflammatory Reactions in Atherosclerosis

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Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

Mild oxidation of LDL by prolonged storage or by mild tratment with iron produced a modified form of LDL that was still recognized by the LDL receptor. This mildly modified LDL (MM-LDL) contained oxidized lipid(s) that caused artery wall cells to express genes whose protein products could account for the cellular events seen in the developing fatty streak, namely: monocyte adherence (Berliner et al., 1990), monocyte migration by monocyte chemotactic protein MCP-1 (Cushing et al., 1990), and monocyte differentiation by macrophage-colony stimulating factor M-CSF (Andalibi et al. Molecular Biology of Atherosclerosis, 1990). We have used a multilayer coculture of human aortic wall endothelial and smooth muscle cells and studied the modification of LDL in this system and the resulting effects on the artery wall cells.

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Author information

Authors and Affiliations

  1. UCLA School of Medicine, 90024-167917, Los Angeles, CA, Italy

    A. Andalibi, S. Hama, S. Imes, R. Gates, M. Navab & A. M. Fogelman

Authors
  1. A. Andalibi
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  2. S. Hama
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  3. S. Imes
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  4. R. Gates
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  5. M. Navab
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  6. A. M. Fogelman
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Editor information

Editors and Affiliations

  1. Department of Experimental Medicine and Oncology, University of Torino, I-101 25, Torino, Italy

    G. Poli , E. Albano  & M. U. Dianzani ,  & 

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© 1993 Birkhäuser Verlag Basel/Switzerland

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Andalibi, A., Hama, S., Imes, S., Gates, R., Navab, M., Fogelman, A.M. (1993). An in Vitro Approach to the Study of Inflammatory Reactions in Atherosclerosis. In: Poli, G., Albano, E., Dianzani, M.U. (eds) Free Radicals: from Basic Science to Medicine. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9116-5_30

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  • DOI: https://doi.org/10.1007/978-3-0348-9116-5_30

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9914-7

  • Online ISBN: 978-3-0348-9116-5

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