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Stress-Inducible Cellular Responses pp 79–95Cite as

Molecular chaperoning of steroid hormone receptors

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Part of the book series: EXS ((EXS,volume 77))

Summary

The study of the large, unactivated form of steroid receptors has led to the discovery of an hsp90/hsp70-based multicomponent protein folding system(s). For steroid receptors, the hsp90 chaperone system determines both repression of transcriptional activity in the absence of hormone and the proper folding of the hormone binding domain to produce the steroid binding conformation. Like steroid receptors, a number of other regulators of transcription and some protein kinases are now known to be associated with hsp90. Given the abundance of the proteins comprising the hsp90 chaperone system and the apparent ubiquity of the system in the animal and plant kingdoms, this system is thought to serve a fundamental role for protein folding, function and possibly trafficking within the cytoplasm and nucleus. In this chapter, we discuss the work on steroid receptor heterocomplex composition that has led to the discovery of new chaperone proteins and we summarize the mechanistic information developed in cell-free studies of receptor heterocomplex assembly.

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Author information

Authors and Affiliations

  1. Department of Pharmocology, University of Michigan, Medical Science Research Building III, 48109-0626, Ann Arbor, MI, USA

    W. B. Pratt

  2. Institut für Biologische Chemie, Universität Heidelberg, Im Neuenheimer Feld 501, D-69120, Heidelberg, Germany

    U. Gehring

  3. Department of Biochemistry and Molecular Biology, Mayo Clinic, 55905, Rochester, MN, USA

    D. O. Toft

Authors
  1. W. B. Pratt
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  2. U. Gehring
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  3. D. O. Toft
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Pratt, W.B., Gehring, U., Toft, D.O. (1996). Molecular chaperoning of steroid hormone receptors. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_6

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_6

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9901-7

  • Online ISBN: 978-3-0348-9088-5

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