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Regulation of thermotolerance and ischemic tolerance

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Stress-Inducible Cellular Responses

Part of the book series: EXS ((EXS,volume 77))

Abstract

Thermotolerance and ischemic tolerance are two major biological aspects where heat shock (stress) proteins exert essential roles for survival in cells as well as in various tissues. Bioflavonoids prevent the cells from acquiring thermotolerance after stresses through specific inhibition in the induction of heat shock proteins. The mechanism of this inhibition is revealed to be due to the prevention of the activation of heat shock factor 1 after heat shock. The induction of stress proteins during the ischemic stress is then described in global as well as focal cerebral ischemic model in rats. The activation of heat shock factor 1 after ischemia is first shown to induce various stress proteins in the central nervous system.

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Authors and Affiliations

  1. Department of Cell Biology, Chest Disease Research Institute, Kyoto University, 53 Kawaharacho, Shogo-inn, Sakyo-ku, Kyoto, 606-01, Japan

    K. Nagata

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  1. K. Nagata
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Nagata, K. (1996). Regulation of thermotolerance and ischemic tolerance. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_31

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_31

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9901-7

  • Online ISBN: 978-3-0348-9088-5

  • eBook Packages: Springer Book Archive

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