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Signaling events controlling the molecular response to genotoxic stress

  • Chapter
Stress-Inducible Cellular Responses

Part of the book series: EXS ((EXS,volume 77))

Summary

Recently, much progress has been made in defining the signal transduction pathways mediating the cellular response to genotoxic stress. Multiple pathways involving several distinct MAP kinases (ERK, JNK/SAPK, and p38/HOG1) as well as the tumor suppressor protein p53 contribute to the response; the various pathways being differentially activated by particular genotoxic agents. Although both DNA damage and extranuclear events are important in initiating the response, recent evidence suggests the response is controlled primarily through events occurring at the plasma membrane, overlapping significantly with those important in initiating mitogenic responses. Attenuation of the responses appears to be largely controlled through feedback mechanisms involving gene products produced during the activation process.

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Authors and Affiliations

  1. Gene Expression and Aging Section, National Institute on Aging, 21244, Baltimore, MD, USA

    N. J. Holbrook & Y. Liu

  2. Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, 20892, MD, USA

    A. J. Fornace Jr.

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  1. N. J. Holbrook
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  2. Y. Liu
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  3. A. J. Fornace Jr.
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Editors and Affiliations

  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Holbrook, N.J., Liu, Y., Fornace, A.J. (1996). Signaling events controlling the molecular response to genotoxic stress. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_18

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_18

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9901-7

  • Online ISBN: 978-3-0348-9088-5

  • eBook Packages: Springer Book Archive

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