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Pro-oxidant and antioxidant effects of nitric oxide

  • Chapter
Analysis of Free Radicals in Biological Systems

Summary

Nitric oxide reacts preferentially with other free radicals. Reaction of nitric oxide with oxygen yields nitrogen dioxide, a potent oxidant. However, this reaction may be too slow to be relevant in vivo. Reaction of nitric oxide with superoxide occurs extremely rapidly and generates peroxynitrite. This latter molecule undergoes many deleterious oxidative reactions with biological molecules such as amino acids, sugars and lipids. In an analagous reaction nitric oxide may also react with peroxyl radicals, such as lipid peroxyl radicals, and inhibit free radical chain reactions such as lipid peroxidation.

This chapter discusses experimental sources of nitric oxide and peroxyntirite and the potential pro-oxidant and antioxidant effects of nitric oxide in biological systems.

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Authors and Affiliations

  1. Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, WI, 53226, USA

    N. Hogg

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  1. N. Hogg
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Editor information

Editors and Affiliations

  1. Laboratoire de Biochimie C, CHU Albert Michallon, BP 217, F-38043, Grenoble Cédex 9, France

    A. E. Favier

  2. CEA/Département de Recherche Fondamentale sur la Matière, Condensée, SESAM/LAN, 17, rue des Martyrs, F-38054, Grenoble Cédex 9, France

    J. Cadet

  3. Biophysics Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI, 53226-0509, USA

    B. Kalyanaraman

  4. Laboratoire de Biochimie Recherche, Domaine Universitaire, F-38400, Saint Martin d’Hères, France

    M. Fontecave

  5. Laboratoire de Chimie Biomimétique LEDSS II, Domaine Universitaire, F-38400, Saint Martin d’Hères, France

    J.-L. Pierre

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Hogg, N. (1995). Pro-oxidant and antioxidant effects of nitric oxide. In: Favier, A.E., Cadet, J., Kalyanaraman, B., Fontecave, M., Pierre, JL. (eds) Analysis of Free Radicals in Biological Systems. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9074-8_4

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  • DOI: https://doi.org/10.1007/978-3-0348-9074-8_4

  • Publisher Name: Birkhäuser Basel

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