Summary
Nitric oxide plays a role in regulation of the vascular tone and platelet aggregation, neuronal transmission and cytostasis. It is generated within cells during oxidation of Larginine catalyzed by NO synthases. Nitric oxide is a radical species, very reactive towards molecular oxygen, superoxide radical, organic radicals and transition metals. During these reactions, ·NO can be converted to NO+, the nitrosonium ion, NO-, the nitroxyl anion or to ONOO-, the peroxynitrite anion. Synthetic ·NO donors are compounds which can decompose into ·NO and may have applications as vasodilators or antiproliferative agents.
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© 1995 Birkhäuser Verlag Basel/Switzerland
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Garrel, C., Fontecave, M. (1995). Nitric oxide: Chemistry and biology. In: Favier, A.E., Cadet, J., Kalyanaraman, B., Fontecave, M., Pierre, JL. (eds) Analysis of Free Radicals in Biological Systems. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9074-8_3
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DOI: https://doi.org/10.1007/978-3-0348-9074-8_3
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