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Tumor cell interactions with the vascular endothelium and their role in cancer metastasis

  • Chapter
Epithelial-Mesenchymal Interactions in Cancer

Part of the book series: Experientia Supplementum ((EXS,volume 74))

Abstract

The prevention of cancer deaths is dependent upon understanding the mechanism of malignant tumor cell spread from primary tumor sites to distant organ sites. Cancer metastases form by way of a complex series of sequential steps involving a variety of tumor cell and host properties. These steps typically involve growth and invasion of malignant cells at primary sites, followed by their penetration into lymphatics and blood circulation and body cavities. Once in these compartments, the malignant cells can detach and be transported to distant sites. There they can implant and invade surrounding tissues, and establish suitable microenvironments for survival and growth. This chapter will deal with the importance of tumor cell-endothelial interactions in the metastatic process.

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  1. Department of Tumor Biology (108), The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas, 77030, USA

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Nicolson, G.L. (1995). Tumor cell interactions with the vascular endothelium and their role in cancer metastasis. In: Goldberg, I.D., Rosen, E.M. (eds) Epithelial-Mesenchymal Interactions in Cancer. Experientia Supplementum, vol 74. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9070-0_7

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