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Nucleic acid based sensors

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Frontiers in Biosensorics I

Part of the book series: Experientia Supplementum ((EXS,volume 80))

Summary

Nucleic acids may be analyte or molecular recognition elements in biosensors. Both aspects merge in the genosensor approach, where detection of special sequences is facilitated by hybridization of a target nucleic acid to a complementary immobilized template. All three roles of nucleic acids in biosensors are discussed and the state of sensor development reviewed. With the invention of evolutionary synthesis strategies applied to nucleic acids new types of biomolecular receptors are accessible. The impact of aptamers and ribozymes on biosensor development is discussed.

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Authors and Affiliations

  1. Institute for Biochemistry and Molecular Physiology, University of Potsdam, c/o Max-Delbrück-Center of Molecular Medicine, Berlin, D-13122, Germany

    F. F. Bier

  2. Institute of Biochemistry, Free University of Berlin, Berlin, D-14195, Germany

    J. P. Früste

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  1. Institut für Biochemie und Molekulare Physiologie c/o Max-Delbrück-Center für Molekulare Medizin, Robert-Rössle-Strasse 10, D-13 122, Berlin, Germany

    F. W. Scheller

  2. Physikalisch-Technische Bundesanstalt, Abbestrasse 2-12, D-10587, Berlin, Germany

    F. Schubert

  3. Centrum für Hochschulentwicklung, PO Box 105, D-33311, Gütersloh, Germany

    J. Fedrowitz

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Bier, F.F., Früste, J.P. (1997). Nucleic acid based sensors. In: Scheller, F.W., Schubert, F., Fedrowitz, J. (eds) Frontiers in Biosensorics I. Experientia Supplementum, vol 80. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-9043-4_7

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  • DOI: https://doi.org/10.1007/978-3-0348-9043-4_7

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