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Molecular mechanisms of neurotransmitter and neuropeptide release

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The Peptidergic Neuron

Part of the book series: Advances in Life Sciences ((ALS))

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Summary

In synaptic transmission, calcium entry into the presynaptic nerve terminal causes docked synaptic vesicles to fuse with the plasma membrane and release their neurotransmitter contents across the synapse. A biochemical pathway for synaptic vesicle docking and fusion is currently being elucidated. The proteins implicated in this pathway are conserved between eukaryotes from yeast to mammals, and isoforms of these proteins mediate vesicle trafficking in a variety of constitutive and regulated transport steps. It is likely that the molecular mechanisms of synaptic vesicle exocytosis also apply to the release of neuropeptides from large dense-core vesicles. We have characterized n-sec1, a cytosolic protein of the nerve terminal that binds syntaxin. We have also identified three mammalian homologues of n-sec1 that may regulate vesicle trafficking between the Golgi apparatus and lysosomes.

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Authors and Affiliations

  1. Department of Neuroscience, The Johns Hopkins School of Medicine and Department of Neurology, The Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD, 21205, USA

    J. Pevsner

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  1. J. Pevsner
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Editors and Affiliations

  1. Anatomisches Institut der Universität zu Kiel, Olshausenstrasse 40, D-24098, Kiel, Germany

    Brigitte Krisch  & Rolf Mentlein  & 

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Pevsner, J. (1996). Molecular mechanisms of neurotransmitter and neuropeptide release. In: Krisch, B., Mentlein, R. (eds) The Peptidergic Neuron. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9010-6_7

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  • DOI: https://doi.org/10.1007/978-3-0348-9010-6_7

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9866-9

  • Online ISBN: 978-3-0348-9010-6

  • eBook Packages: Springer Book Archive

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