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The Peptidergic Neuron pp 21–38Cite as

Role of convertases in the processing of neuropeptides and neurotrophins

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Part of the book series: Advances in Life Sciences ((ALS))

Summary

The hypothesis that endoproteolytic cleavage of large precursor proteins produces hormonal peptides has been extended to neuropeptides and neurotrophins. The wide distribution of 7 known proprotein convertases in the brain, along with the presence of a large number of substrates, indicate that these enzymes participate in numerous brain functions. Co-localization of convertases with their putative substrates along with in vivo co-expression studies are key experiments to define the relationship between each individual substrate with its appropriate convertase. These developments bring new lights to the understanding of brain functions and development.

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Abbreviations

ACTH:

adrenocorticotropic hormone

ANF:

atrial natruretic factor

BDNF:

brain derived-neurotrophic factor

BPN’:

bacterial subtilisin

CLIP:

corticotropin-like intermediate lobe peptide

EGF:

epidermal growth factor

END:

endorphin

GDNF:

glia-derived neurotrophic factor

HIVgp :

human immunodeficiency virus glycoprotein

IGF:

insulin-like growth factor

JP:

joining peptide

LHRH:

luteinizing hormone-releasing hormone

LPH:

lipotropic hormone

MSH:

melanocyte-stimulating hormone

NGF:

nerve growth factor

NT:

neurotrophin

PA:

pseudomonas antrax toxin

PACE4:

paired base amino acids-converting enzyme 4

PC:

proprotein convertases

PDGF:

platelet-derived growth factor

POMC:

pro-opiomelanocortin

PTH:

parathormone

PTP:

phosphotyrosine phosphatase receptor

TGF:

transforming growth factor

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Author information

Authors and Affiliations

  1. Laboratories of Molecular Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC, H2W, 1R7, Canada

    M. Chrétien, S. Benjannet & M. Marcinkiewicz

  2. Clinical Research Institute of Montreal, Laboratories of Biochemical Neuroendocrinology, 110 Pine Avenue West, Montreal, QC, H2W 1R7, Canada

    R. Day & N. G. Seidah

Authors
  1. M. Chrétien
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  2. S. Benjannet
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  3. M. Marcinkiewicz
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  4. R. Day
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  5. N. G. Seidah
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Editor information

Editors and Affiliations

  1. Anatomisches Institut der Universität zu Kiel, Olshausenstrasse 40, D-24098, Kiel, Germany

    Brigitte Krisch  & Rolf Mentlein  & 

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Chrétien, M., Benjannet, S., Marcinkiewicz, M., Day, R., Seidah, N.G. (1996). Role of convertases in the processing of neuropeptides and neurotrophins. In: Krisch, B., Mentlein, R. (eds) The Peptidergic Neuron. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9010-6_4

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  • DOI: https://doi.org/10.1007/978-3-0348-9010-6_4

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9866-9

  • Online ISBN: 978-3-0348-9010-6

  • eBook Packages: Springer Book Archive

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