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Regulation of angiogenesis in malignant gliomas

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Book cover Regulation of Angiogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 79))

Summary

Gliomas are highly resistant to conventional therapeutic measures, requiring the development of novel treatments. Since gliomas are particularly vascular tumors, one approach involves treatments directed at inhibiting angiogenic mechanisms. Although multiple factors contribute to the ultimate vascularization of any tumor, some are especially relevant to gliomas. Early experimental work directed at inhibiting angiogenic pathways has shown promise toward achieving control of tumor growth. This article focuses on the evidence that angiogenesis and related vascular cell responses play important roles in glioma biology, and reviews those biochemical pathways known through experimentation to be involved in the vascular response to gliomas. Finally, contemporary vessel-targeted approaches that have been used to inhibit glioma growth are discussed.

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Authors and Affiliations

  1. Department of Neurosurgery, National Naval Medical Center, Bethesda, Maryland, 20889-5000, USA

    C. Guerin

  2. Departments of Neurology, Oncology, and Neuroscience, The Johns Hopkins School of Medicine and The Kennedy Krieger Institute, Baltimore, Maryland, 21205, USA

    J. Laterra

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  1. C. Guerin
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  1. Department of Radiation Oncology, Long Island Jewish Medical Center, 270-05 76th Avenue New Hyde Park, 11042, New York, NY, USA

    Itzhak D. Goldberg M.D.  & Eliot M. Rosen M.D. Ph.D.  & 

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© 1997 Birkhäuser Verlag Basel, Switzerland

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Guerin, C., Laterra, J. (1997). Regulation of angiogenesis in malignant gliomas. In: Goldberg, I.D., Rosen, E.M. (eds) Regulation of Angiogenesis. Experientia Supplementum, vol 79. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9006-9_4

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  • DOI: https://doi.org/10.1007/978-3-0348-9006-9_4

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