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Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo pp 171–189Cite as

The Sheep as a Model of the Late Asthmatic Response

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Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

The sheep model of allergic bronchoconstriction has been extensively used to study the pathobiology of asthma, but may be most noted for its use as a model of antigen-induced late phase airway responses (late asthmatic response, LAR). The intense interest in the late response is, in part, due to epidemiological data which suggest that patients who develop late antigen-induced responses in the laboratory suffer from more severe asthma [1]. Thus, understanding the mechanisms leading to the development of late responses could be important in identifying factors that influence asthma severity. The following chapter provides a summary of the pathophysiological and pharmacological studies in the sheep model and how these studies have been used to understand the mechanisms operative in allergic bronchoconstriction and inflammation.

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Authors and Affiliations

  1. Division of Pulmonary Diseases, University of Miami at Mount Sinai Medical Center, Miami Beach, Florida, USA

    William M. Abraham

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  1. William M. Abraham
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  1. Discovery Biology, Rhône-Poulenc Rorer Ltd Dagenham Research Centre, Dagenham, RM10 7XS, Essex, England

    David Raeburn

  2. Department of Thoracic Medicine, National Heart and Lung Institute Imperial College of Science, Technology and Medicine, SW3 6LY, London, England

    Mark A. Giembycz

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Abraham, W.M. (1996). The Sheep as a Model of the Late Asthmatic Response. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo . Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9000-7_8

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  • DOI: https://doi.org/10.1007/978-3-0348-9000-7_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9863-8

  • Online ISBN: 978-3-0348-9000-7

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