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PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs

  • Chapter
Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

The guinea pig has long been recognised as an appropriate experimental animal in which several of the pathological characteristics of asthma can be modelled [1]. Such pathology includes the development of polyphasic reactions [2, 3], the selectively eosinophilic nature of the pulmonary cell infiltrate and the induction of airways hyperresponsiveness following exposure of actively sensitized animals to allergen [4–6]. Moreover, several of these pathological characteristics are modified by established anti-asthma therapies in the guinea pig [6],indication the utility of this species as a relevant animal model for novel drug selection.

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Authors and Affiliations

  1. Department of Pharmacology, Quintiles Scotland Ltd, Riccarton, Edinburgh, Scotland, UK

    Aileen A. Y. Milne & Ian D. Chapman

  2. Respiratory Medicine Unit, Department of Medicine, (RIE), Rayne Laboratory, University of Edinburgh Medical School, Edinburgh, Scotland, UK

    Adriano G. Rossi

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  1. Aileen A. Y. Milne
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  2. Adriano G. Rossi
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  3. Ian D. Chapman
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Editors and Affiliations

  1. Discovery Biology, Rhône-Poulenc Rorer Ltd Dagenham Research Centre, Dagenham, RM10 7XS, Essex, England

    David Raeburn

  2. Department of Thoracic Medicine, National Heart and Lung Institute Imperial College of Science, Technology and Medicine, SW3 6LY, London, England

    Mark A. Giembycz

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Milne, A.A.Y., Rossi, A.G., Chapman, I.D. (1996). PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo . Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9000-7_3

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  • DOI: https://doi.org/10.1007/978-3-0348-9000-7_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9863-8

  • Online ISBN: 978-3-0348-9000-7

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