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Transgenic Animals and the Modelling of Asthma

  • Chapter
Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

The exact cellular and molecular events leading to airways obstruction and physiological dysregulation in asthma have not been fully defined through human experimentation in vivo. Significant genetic, pathophysiological and clinical variation in the presentation and natural history of asthma complicates this experimentation. Obvious economic and ethical concerns also limit the investigation of asthma in human subjects. Nevertheless, direct examination of specimens from asthmatics has led to an important shift in our concept of the pathogenesis of this disorder. It is now widely held that asthma is a chronic inflammatory disorder and that the obstruction and airways hyperresponsiveness (AHR) that are characteristic of asthma are largely the result of this inflammatory response and its fibrotic and tissue-damaging sequellae. As a result, anti-inflammatory interventions are now the cornerstone of asthma therapy and the inflammatory mechanisms of asthma are now the major focus of research activities in this field. In spite of this insight, the role that individual mediators play in asthmatic inflammation, the fundamental molecular mechanisms leading to the chronicity of asthmatic inflamation, and the events linking inflammation, bronchoconstriction and bronchial reactivity remain important, inadequately addressed areas in the pathogenesis of this disorders.

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Authors and Affiliations

  1. Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    Robert Schilz & Jack A. Elias

  2. Department of Internal Medicine, Research Service, West Haven Veterans Administration Medical Center, West Haven, Connecticut, USA

    Jack A. Elias

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  1. Robert Schilz
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  1. Discovery Biology, RhĂ´ne-Poulenc Rorer Ltd Dagenham Research Centre, Dagenham, RM10 7XS, Essex, England

    David Raeburn

  2. Department of Thoracic Medicine, National Heart and Lung Institute Imperial College of Science, Technology and Medicine, SW3 6LY, London, England

    Mark A. Giembycz

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Schilz, R., Elias, J.A. (1996). Transgenic Animals and the Modelling of Asthma. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo . Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9000-7_11

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  • DOI: https://doi.org/10.1007/978-3-0348-9000-7_11

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