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Measurement of Airways Smooth Muscle Responsiveness in Animals

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Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

The patency of the airway is regulated by airways smooth muscle which is under humoral and neural control, and also by other lung structures including the chest wall. Airway narrowing is an important defence mechanism against inhaled irritants and particles. An abnormal constriction of the bronchial tree, such as in asthma and chronic bronchitis, will result in a diminished capacity of the lungs to oxygenate the blood, which will eventually restrict physical activity and reduce the quality of life. Unfortunately, the prevalence, morbidity and mortality of these lung diseases continue to increase despite the introduction of new medicines and altered treatment guidelines. Consequently research into the regulation of airways smooth muscle in vitro and in vivo has attracted much interest.

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Authors and Affiliations

  1. Rhône-Poulenc Rorer Ltd., Dagenham Research Centre, Dagenham, Essex, UK

    Steve Webber & Jan-Anders Karlsson

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  1. Steve Webber
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  2. Jan-Anders Karlsson
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Editors and Affiliations

  1. Discovery Biology, Rhône-Poulenc Rorer Ltd Dagenham Research Centre, Dagenham, RM10 7XS, Essex, England

    David Raeburn

  2. Department of Thoracic Medicine, National Heart and Lung Institute Imperial College of Science, Technology and Medicine, SW3 6LY, London, England

    Mark A. Giembycz

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Webber, S., Karlsson, JA. (1996). Measurement of Airways Smooth Muscle Responsiveness in Animals. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo . Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9000-7_1

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  • DOI: https://doi.org/10.1007/978-3-0348-9000-7_1

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9863-8

  • Online ISBN: 978-3-0348-9000-7

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