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Electrophysiological responses to ischemia and reperfusion

  • Chapter
Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

Abstract

Myocardial ischemia, defined as an imbalance between energetic demands of the heart and supply of metabolic substrates (inclusive of O2), produces profound changes in cardiac electrical activity which can eventually lead to the development of severe arrhythmias and sudden death. While reperfusion of ischemic myocardium reduces or prevents myocardial necrosis, this procedure may also lead to arrhythmia development, contractile failure and the precipitation of cell death. Although both processes, ischemic and reperfusion injury may share the end point of inducing acute cardiac failure, the cellular events and the mechanisms involved may differ considerably.

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Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Sherbrooke, J1H 5N4, Sherbrooke, Quebec, Canada

    E. Ruiz Petrich (Faculty of Medicine) & O. F. Schanne (Faculty of Medicine)

  2. Department of Physiology, University of Cuyo, Medical Sciences Building, N6A 5C1, Mendoza, Argentina

    A. Ponce Zumino

Authors
  1. E. Ruiz Petrich
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  2. O. F. Schanne
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  3. A. Ponce Zumino
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Ruiz Petrich, E., Schanne, O.F., Ponce Zumino, A. (1996). Electrophysiological responses to ischemia and reperfusion. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

  • eBook Packages: Springer Book Archive

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