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The roles of free radicals, peroxides and oxidized lipoproteins in second messenger system dysfunction

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

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Abstract

In living tissue, cells are constantly exposed to a wide variety of sources of oxidative stress under both physiologic and pathologic situations [1]. In most circumstances, the cell’s built-in defense mechanisms ensure that these stresses do not overwhelm the normal functioning of the cellular machinery [1]. In situations of acute or chronic stress or disease, however, these defense mechanisms may be overwhelmed or incapacitated. When this occurs, the cell may be destroyed, or its ability to properly function impaired, which in turn may lead to secondary disease processes.

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Author information

Authors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Canada

    M. P. Czubryt, V. Panagia & G. N. Pierce

  2. Department of Physiology, University of Manitoba, R2H 2A6, Winnipeg, Manitoba, Canada

    M. P. Czubryt, V. Panagia & G. N. Pierce

Authors
  1. M. P. Czubryt
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  2. V. Panagia
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  3. G. N. Pierce
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Czubryt, M.P., Panagia, V., Pierce, G.N. (1996). The roles of free radicals, peroxides and oxidized lipoproteins in second messenger system dysfunction. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_4

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

  • eBook Packages: Springer Book Archive

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