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Pharmacological intervention in post-infarction wound healing

  • Chapter
Book cover Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

Abstract

The importance, implications, and potential value of pharmacologic interventions during healing of the wound of myocardial infarction have become apparent as a result of recent advances in pathophysiology of healing and ventricular remodeling post-infarction. Over the last three decades, therapeutic efforts after myocardial infarction have centered around minimizing the loss of myocardium and function. Therapy focused on acute reduction of myocardial infarct size in the mid-seventies and on restoration of perfusion in the infarct zone in the mid-eighties. Over the last decade, chronic therapies have been developed for prevention of ventricular remodeling, progressive ventricular dilation and ventricular dysfunction [1, 2]. It became evident during the last 30 years that some pharmacologic therapies aimed at salvaging ischemic myocardium also exerted other effects on infarct healing, and those with clearly adverse effects were best avoided [3–7]. Recognition that the substrate for ventricular remodeling changes during infarct healing led to the suggestion that timing and duration of specific antiremodeling interventions should be based on knowledge of the natural pathophysiologic stage of healing in order to maximize therapeutic benefits [2, 8, 9]. To date, therapies have not been primarily targeted at improving the healing process post-infarction. This chapter will review current and potential pharmacologic interventions in post-infarction wound healing.

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Authors and Affiliations

  1. Cardiology Division, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada, T6G 2R7

    B. I. Jugdutt

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  1. B. I. Jugdutt
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Jugdutt, B.I. (1996). Pharmacological intervention in post-infarction wound healing. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_31

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_31

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

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