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Ischemic preconditioning against infarction: Its mechanism and clinical implications

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

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Summary

Exposing the myocardium to brief ischemia followed by reperfusion enhances myocardial resistance to infarction from a subsequent sustained ischemia. This phenomenon, termed preconditioning, is most likely to be triggered by adenosine Al receptor activation, and the dependence of the preconditioning effect on the duration of preconditioning ischemia and the number of its repetitions is probably through the interstitial adenosine level achieved by each preconditioning protocol. Our studies support the theory that activation of protein kinase C subsequent to stimulation of the Al receptor enhances myocardial ischemic tolerance. The ATP-sensitive potassium channel may be involved in preconditioning, but its relation with protein kinase C is unclear, and the relative importance of this channel might be species dependent. The mechanism of preconditioning needs to be further elucidated in animal models and preconditioning in the human heart needs to be further characterized before we can adapt its biochemical basis to clinical therapy.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, 060, Japan

    T. Miura, T. Miki, K. Tsuchihashi & O. Iimura

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  1. T. Miura
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  2. T. Miki
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  3. K. Tsuchihashi
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Berkhäuser Verlag Basel/Switzerland

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Miura, T., Miki, T., Tsuchihashi, K., Iimura, O. (1996). Ischemic preconditioning against infarction: Its mechanism and clinical implications. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_22

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_22

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

  • eBook Packages: Springer Book Archive

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