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Role of the sympathetic nervous system in the ischemic and reperfused heart

  • Chapter
Book cover Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

Abstract

Norepinephrine, that has been released from sympathetic nerve endings in response to myocardial ischemia, may have either a beneficial or a harmful effect on the ischemic heart. If the duration of ischemia is short, the release of norepinephrine may be favorable for the production of energy and for protection of the heart against ischemic damage. If the duration of ischemia is prolonged, there is a marked increase in number of both α1- and ß-adrenocep-tors located in the sarcolemmal membrane, as well as an excessive increase in release of norepinephrine. These events during the prolonged period of ischemia can produce an imbalance between oxygen supply and demand, which is harmful to the heart. The anti-ischemic effect of α1 and ß-adrenoceptor antagonists is not attributed merely to improvement of oxygen balance, but reduction of phospholipase activity or stabilization of membrane may also be important as an underlying mechanism.

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Authors and Affiliations

  1. Department of Pharmacology, Asahikawa Medical College, Asahikawa, 078, Japan

    A. Hara & Y. Abiko

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  1. A. Hara
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  2. Y. Abiko
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Hara, A., Abiko, Y. (1996). Role of the sympathetic nervous system in the ischemic and reperfused heart. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_17

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_17

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

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