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Insertion Sequences as Genomic Markers

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Prokaryotic Genomics

Part of the book series: Methods and Tools in Biosciences and Medicine ((MTBM))

Abstract

Mobile genetic elements are widespread in almost all living organisms. This chapter will focus on insertion sequence (IS) elements, which are bacterial mobile genetic elements carrying genetic information devoted to their transposition and its regulation [1]. IS elements, and more generally mobile genetic elements, were first discovered by their ability to generate mutations [2, 3], and several studies suggested their significant contribution to spontaneous mutagenesis in bacteria [4, 5]. Transposition of an IS element can result in gene inactivation, polar effects [6, 7], activation of cryptic genes, and modification of gene expression (for review, see [1]). Besides these “simple” transposition events, IS elements can be involved in global restructuring of genomes, through homologous recombination events between homologous copies. Chromosomal rearrangements such as inversions, deletions, and duplications have been described [8, 9].

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Authors
  1. Dominique Schneider
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  2. Michel Blot
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Editors and Affiliations

  1. Université Joseph Fourier, 460 rue de la piscine, 38400, St Martin d’Hères, France

    Michel Blot

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© 2003 Birkhäuser Verlag Basel/Switzerland

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Schneider, D., Blot, M. (2003). Insertion Sequences as Genomic Markers. In: Blot, M. (eds) Prokaryotic Genomics. Methods and Tools in Biosciences and Medicine. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8963-6_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8963-6_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-6596-7

  • Online ISBN: 978-3-0348-8963-6

  • eBook Packages: Springer Book Archive

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