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Neuronal prostacyclin receptors

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

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Abstract

Prostacyclin is primarily derived from vascular endothelium and has traditionally been regarded as an important regulator of haemostasis due to its potent anti-platelet and vasodilator activity [1]. However, prostacyclin has additional biological activity mediated by receptors located in both the peripheral and central nervous system (CNS), and it is recent developments in the study of these neuronal prostacyclin receptors (IP-receptors) which form the basis of the following review. These are early days still in our understanding of the neuronal function of prostacyclin; I hope therefore that this review will set the scene for what is a rapidly developing and exciting area of research. To date only one IP-receptor has been isolated and cloned [2], and this represents the classical IP-receptor present in platelets. While evidence will be presented for the existence of subtypes of the IP-receptor, to date none of these have been cloned. Therefore to avoid the use of possibly inappropriate nomenclature, I shall refer to the subtypes with respect to their primary location, for example enteric IP-receptors or neuronal IP-receptors.

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  1. Department of Pharmacology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

    Helen Wise

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    Ernst Jucker

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Wise, H. (1997). Neuronal prostacyclin receptors. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 49. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8863-9_4

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