Abstract
In 1993, Progress in Drug Research published a review dealing with mechanisms of teratogenic/embryotoxic effects of chemicals on humans and other vertebrates [1] and covering the literature through 1992. Since 1992, significant strides have been made in understanding the biochemical and molecular mechanisms whereby chemicals are capable of eliciting birth defects as the result of prenatal exposure of conceptuses to such chemicals. These strides thus justify this review, which accordingly will focus primarily on research published since 1992 and extending through 1996. Emphasis will be directed toward those chemicals/chemical classes that are frequently regarded at present [1–5] as capable of producing birth defects in humans (“established” or “recognized” human teratogens). Most of the chemicals commonly regarded as established human teratogens (Tables 1 and 2) are xenobiotics, i.e., exogenous chemicals that are not utilized by the reference organism as nutrient materials, are not essential to the reference organism for maintenance of normal physiologic/biochemical function and homeostasis, and do not constitute a part of the conventional array of chemicals synthesized from nutrient chemicals by the reference organism in normal intermediary metabolism. Such xenobiotic chemicals are thus also often classified as “foreign”.
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Juchau, M.R. (1997). Chemical teratogenesis in humans: Biochemical and molecular mechanisms. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 49. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8863-9_2
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