Skip to main content
SpringerLink
Log in
SpringerLink
Log in

5-Hydroxytryptamine (5-HT)4 receptors and central nervous system function: An update

  • Chapter
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Abstract

The 5-hydroxytryptamine (5-HT; serotonin)4 receptor is one of three 5-HT receptor subtypes that couple positively to adenylyl cyclase, the others being the 5-HT6 and 5-HT7 receptors [1]. In terms of sequence homology and pharmacology, these receptors are distinct and have differing distributions and function. In the last 5 years or so, the 5-HT4 receptor has become the focus of much interest in both academia and the pharmaceutical industry. Elucidation of the role of the receptor in the central and peripheral nervous systems is thus emerging, and novel therapeutics with 5-HT4 receptor selectivity are currently in advanced clinical trials.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. T.A. Branchek: Semin. Neurol. 7, 375–382 (1996).

    Google Scholar 

  2. S.S. Hegde and R.M. Eglen: FASEB J. 10 1398–1407 (1996).

    PubMed  CAS  Google Scholar 

  3. A. Shenker, S. Maayani, H. Weinstein and IP. Green: Eur. J. Pharmacol. 109 427–429 (1985).

    Article  PubMed  CAS  Google Scholar 

  4. A. Dumuis, R. Bouhelal, M. Sebben and J. Bockaert: Eur. J. Pharmacol. 146 187–188 (1988).

    Article  PubMed  CAS  Google Scholar 

  5. A. Dumuis, R. Bouhelal, M. Sebben, R. Cory and J. Bockaert: Mol. Pharmacol. 34 880–887 (1988).

    PubMed  CAS  Google Scholar 

  6. C. Gerald, N. Adham, H.-T. Kao, M.A. Olsen, T.M. Laz, L.E. Schecter, J.A. Bard, P.J.-J. Vaysse, P.R. Hartig, T.A. Branchek and R.L. Weinshank: EMBO J. 14 2806–2815 (1995).

    PubMed  CAS  Google Scholar 

  7. L.M. Gaster and F.D. King: Med. Res. Rev. 17 163–214 (1997).

    Article  PubMed  CAS  Google Scholar 

  8. R.M. Eglen, E.H.F. Wong, A. Dumuis and J. Bockaert: Trends Pharmacol. Sci. 16, 391–398 (1995).

    Article  PubMed  CAS  Google Scholar 

  9. R.M. Eglen and S.S. Hegde: Exp. Opin. Invest. Drugs 5, 373–388 (1996).

    Article  CAS  Google Scholar 

  10. A.P.D.W. Ford and D.E. Clarke: Med. Res. Rev. 13, 633–662 (1993).

    Article  PubMed  CAS  Google Scholar 

  11. International patent number WO 94/14957.

    Google Scholar 

  12. S. Claeysen, M. Sebben, L. Journot, J. Bockaert and A. Dumuis: FEBS Lett. 398, 19–25 (1996).

    Article  PubMed  CAS  Google Scholar 

  13. N. Adham, C. Gerald, L. Schecter, P. Vaysse, R. Weinshank and T. Branchek: Eur. J. Pharmacol. 304, 231–235 (1996).

    Article  PubMed  CAS  Google Scholar 

  14. H. Ansanay, M. Sebben, J. Bockaert and A. Dumuis: Eur. J. Pharmacol. 298, 165–174 (1996).

    Article  PubMed  CAS  Google Scholar 

  15. E. Monferini, P. Gaetani, R. Rodriguez y Baena, E. Giraldo, M. Parenti, A. Zocchetti and C.A Rizzi: Life Sci. 52, PL61–65 (1993).

    Article  Google Scholar 

  16. M. Langlois, L. Zhang, D. Yang, B. Bremont, S. Shen, L. Manara and T. Croci: Bio-organ. Med. Chem. Lett. 4, 1433–1436 (1994).

    Article  CAS  Google Scholar 

  17. D. Yang, J.-L. Soulier, S. Sacsic, M. Mathe-Allainmat, B. Bremont, T. Croci, R. Car-damone, G. Aureggi and M. Langlois: J. Med. Chem. 40, 608–621 (1997).

    Article  PubMed  CAS  Google Scholar 

  18. R.D. Clark, A. Jahangir, J.A. Langston, K.K. Weinhardt, A.B. Miller, E. Leung and R.M. Eglen: Bioorgan. Med. Chem. Lett. 4, 2477–2480 (1994).

    Article  CAS  Google Scholar 

  19. R.M. Eglen, D.W. Bonhaus, L.G. Johnson, E. Leung and R.D. Clark: Br. I Pharmacol. 115, 1387–1392 (1995).

    Article  CAS  Google Scholar 

  20. J.D. Gale, C.J. Grossman, J.W. Whitehead, A.W. Oxford, K.T. Bunce and P.P. Humphrey: Br. J. Pharmacol. 111, 332–338 (1994).

    Article  PubMed  CAS  Google Scholar 

  21. K.A. Wardle, E.S. Elliss, G.S. Baxter, G.A. Kennett, L.M. Gaster and G.J. Sanger: Br. J. Pharmacol. 112, 789–794 (1994).

    Article  PubMed  CAS  Google Scholar 

  22. J. Gale, A. Green, R.S. Sargent, N.M. Clayton and K.T. Bunce: Br. J. Pharmacol. 773, 119P.

    Google Scholar 

  23. L.M. Gaster, G.E Joiner, F.D. King, P.A. Wyman, J.M. Sutton, S. Bingham, E.S. Ellis, G.J. Sanger and K.A. Wardle: J. Med. Chem. 38, 4760–4763 (1995).

    Article  PubMed  CAS  Google Scholar 

  24. K.A. Wardle, S. Bingham, E.S. Ellis, L.M. Gaster, B. Rushant, M.I. Smith and G.J. Sanger: Br. J. Pharmacol. 118, 665–670 (1996).

    Article  PubMed  CAS  Google Scholar 

  25. S.S Hegde, D.W. Bonhaus, L.G. Johnson, E. Leung, R.D. Clark and R.M. Eglen: Br. J. Pharmacol. 115, 1087–1095 (1995).

    Article  PubMed  CAS  Google Scholar 

  26. R.D. Clark, A. Jahangir, L.A. Flippen, A.B. Miller, E. Leung, D.W. Bonhaus, E.H.E Wong and R.M. Eglen: Bioorgan. Med. Chem. Lett. 5, 2119–2122 (1995).

    Article  CAS  Google Scholar 

  27. A.J. Kaumann: Trends Pharmacol. Sci. 75, 451–455 (1994).

    Article  Google Scholar 

  28. E. Leung, M.T. Pulido-Rios, D.W. Bonhaus, L.A. Perkins, K.D. Zeitung, S.A.O. Hsu, R.D. Clark, E.H.F. Wong and R.M. Eglen: Naunyn Schmiedebergs Arch. Pharmacol. 354, 145–156 (1996).

    Article  PubMed  CAS  Google Scholar 

  29. C. Ullmer, P. Engels, S. Abdel’Al and H. Lubbert: Naunyn Schmiedebergs Arch. Pharmacol. 354, 210–212 (1996).

    Article  PubMed  CAS  Google Scholar 

  30. M.T. Vilaro, R. Cortes, C. Gerald, T.A. Branchek, J.M. Palacios and G. Mengod: Mol. Brain Res. 43, 356–360 (1996).

    Article  PubMed  CAS  Google Scholar 

  31. C.J. Grossman, G.J. Kilpatrick and K.T. Bunce: Br. J. Pharmacol. 109, 618–624 (1993).

    Article  PubMed  CAS  Google Scholar 

  32. A.J. Kaumann, J.A. Lynham and A. Brown: Br. J. Pharmacol. 115, 933–936 (1995).

    Article  PubMed  CAS  Google Scholar 

  33. C. Waeber, M. Sebben, A. Nieoullon, J. Bockaert and A. Dumuis: Neuropharmacol. 53, 527–541 (1994).

    Article  Google Scholar 

  34. T. Domenech, J. Beleta, A.G. Fernandez, R.W. Gristwood, F. Cruz Sachez, E. Tolosa and J.M. Palacios: Mol. Brain Res. 21, 17–180 (1994).

    Article  Google Scholar 

  35. L.B. Jakeman, Z.P. To, R.M. Eglen, E.H.F. Wong and D.W. Bonhaus: Neuropharmacol. 33, 1027–1038 (1994).

    Article  CAS  Google Scholar 

  36. V. Compan, A. Dazuta, P. Salin, M. Sebben, UJ. Bockaert and A. Dumuis: Eur. J. Neurosci. 8, 2591–2598 (1996).

    Article  PubMed  CAS  Google Scholar 

  37. G.B. Schiavi, S. Brunet, C.A. Rizzi and H. Ladinsky: Neuropharmacol. 33, 543–549 (1994).

    Article  CAS  Google Scholar 

  38. Y. Uchiyama-Tsuyuki, M. Saitoh and M. Muramatsu: Life Sci. 59, 2129–2137 (1996).

    Article  PubMed  CAS  Google Scholar 

  39. G.P. Reynolds, S.L. Mason, A. Meldrum, S. De Keczer, H. Parnes, R.M. Eglen and E.H.F. Wong: Br. J. Pharmacol. 114, 993–998 (1995).

    Article  PubMed  CAS  Google Scholar 

  40. S. Benloucif, M.J. Keegan and M.P. Galloway: J. Pharm Exp.Ther. 265, 373–377 (1993).

    CAS  Google Scholar 

  41. G.J. Kilpatrick, R.M. Hagan and J.D. Gale: Behav. Brain Res. 73, 11–13 (1996).

    Article  PubMed  CAS  Google Scholar 

  42. N. Bonhomme, P. De Deurwaerdere, M. Le Moal and U. Spampinato: Neuropharmacol. 34, 269–279 (1995).

    Article  CAS  Google Scholar 

  43. L.J. Steward, J. Ge, R.L. Stowe, D.C. Brown, R.K. Brunton, PR. Stokes and N.M. Barnes: Br. J. Pharmacol. 117, 55–62 (1996).

    Article  PubMed  CAS  Google Scholar 

  44. P. De Deurwaerdere, M. Bonhomme, G. Lucas, A. Cheramy and U. Spampinato: J. Neurochem. 68, 195–203 (1997).

    Article  PubMed  Google Scholar 

  45. L. Pozzi, L. Trabaee, R. Invernizzi and R. Samanin: Brain Res. 692, 265–268 (1995).

    Article  PubMed  CAS  Google Scholar 

  46. C. Reavill, J.P. Hatcher, T.S.C. Zetterstrom, V.A. Lewis, G.J. Sänger, J.J. Hagan and S. McKay: Br. I Pharmacol. 118, 71P (1996).

    Google Scholar 

  47. A.P. Sempere, J. Duarte, C. Cabezas, L.E. Claveria and F. Coria: Clin. Neurophar-maeol. 18, 76–78 (1995).

    Article  CAS  Google Scholar 

  48. J. Ge and N.M. Barnes: Br. J. Pharmacol. 117, 1475–1480 (1996).

    Article  PubMed  CAS  Google Scholar 

  49. H. Kilbinger, A. Gerbauer, J. Haas, H. Ladinsky and C.A. Rizzi: Naunyn Schmiedebergs Arch. Pharmacol. 351, 229–236 (1995).

    Article  PubMed  CAS  Google Scholar 

  50. S. Consolo, S. Arnaboldi, S. Giorgi, G. Russi and H. Ladinsky: Neuroreport 5, 1230–1232 (1994).

    Article  PubMed  CAS  Google Scholar 

  51. H.G.W.M. Boddeke and H.O. Kakman: Br. J. Pharmacol. 101, 281–284 (1990).

    Article  PubMed  CAS  Google Scholar 

  52. R. Andrade and Y. Chaput: J. Pharmacol. Exp. Ther. 257, 930–937 (1991).

    PubMed  CAS  Google Scholar 

  53. G.E. Torres, I.L. Holt and R. Andrade: J. Pharmacol. Exp. Ther. 271, 255–261 (1994).

    PubMed  CAS  Google Scholar 

  54. G.E. Torres, Y. Chaput and R. Andrade: Mol. Pharmacol. 47, 191–197 (1995).

    PubMed  CAS  Google Scholar 

  55. S. Rowchowdhury, H. Haas and E.G. Anderson: Neuropharmacol. 33, 551–557 (1994).

    Article  Google Scholar 

  56. M. Bijak, K. Tokarski and J. Maj: Naunyn Schmiedebergs Arch. Pharmacol. 355, 14–19 (1997).

    Article  PubMed  CAS  Google Scholar 

  57. M. Simizu, A. Nishida, H. Fukuda, H. Saito and S. Yamawaki: Br. J. Pharmacol. 114, 1282–1288 (1995).

    Article  Google Scholar 

  58. E.R. Kandel and J.H. Schwartz: Science 218, 433–438 (1982).

    Article  PubMed  CAS  Google Scholar 

  59. R. Bourtchuladze, B. Frenguelli, J. Blendy, D. Cioffi, G. Schultz and A. Silva: Cell 79, 59–68 (1994).

    Article  PubMed  CAS  Google Scholar 

  60. H. Ansanay, A. Dumuis, M. Sebben, J. Bockaert and J. Fagni: Proc. Natl. Acad. Sci. USA 92, 6635–6639 (1995).

    Article  PubMed  CAS  Google Scholar 

  61. D.J. Fontana, S. Daniels, C. Henderson, R.M. Eglen and E.H.F. Wong: 3rd IUPHAR Satellite on Serotonin, Chicago, 30 July-3 August, abstract no. 5 (1994).

    Google Scholar 

  62. C. Ghelardini, P. Meoni, N. Galeotti, P. Malmberg-Aiello, C.A. Rizzi and A. Barto-lini: 3rd IUPHAR Satellite on Serotonin, Chicago, 30 July-3 August, abstract no. 1 (1994).

    Google Scholar 

  63. D.J. Fontana, S. Daniels, E.H.F. Wong, R.D. Clark and R.M. Eglen: Neuropharmacol. (in press) (1997).

    Google Scholar 

  64. S. Letty, R. Child, A. Dumuis, A. Pantaloni, J. Bockaert and G. Rondouin: Neuropharmacol. (in press) (1997).

    Google Scholar 

  65. S. Birstiel and S.G. Beck: J. Pharmacol. Exp. Ther. 273, 1132–1138 (1995).

    Google Scholar 

  66. V. Contesse, C. Hamel, C. Delarue, H. Lefebvre and H. Vaudry: Eur. J. Pharmacol. 265, 27–33 (1994).

    Article  PubMed  CAS  Google Scholar 

  67. C.H. Cheng, B. Costall, M.E. Kelly and R.J. Naylor: Eur. J. Pharmacol. 255, 39–49 (1994).

    Article  PubMed  CAS  Google Scholar 

  68. B. Costall and R.J. Naylor: Br. J. Pharmacol. 119, 348P (1996).

    Google Scholar 

  69. B. Costall and R.J. Naylor: Br. J. Pharmacol. 119, 352P (1996).

    Google Scholar 

  70. B. Costall and R.J. Naylor: Int. Clin. Psychopharmacol. 8, 11–18 (1993).

    Article  PubMed  Google Scholar 

  71. IS. Silvestre, A.G. Fernandez and J.M. Palacios: Eur. J. Pharmacol. 309, 219–222 (1996).

    Article  PubMed  CAS  Google Scholar 

  72. G.A. Kennett, F. Bright, B. Trail, T.P. Blackburn and G.J. Sanger: Br. J. Pharmacol. 120, 138P (1997).

    Google Scholar 

  73. N. Andrews and S.E. File: Eur. J. Pharmacol. 235, 109–112 (1993).

    Article  PubMed  CAS  Google Scholar 

  74. C. Ghelardini, N. Galeotti, F. Casamenti, P. Malmberg-Aiello, G. Pepeu, F. Gaultieri and A. Bartolini: Life Sci. 58, 2297–2309 (1996).

    Article  PubMed  CAS  Google Scholar 

  75. M.N. Romanelli, A. Bartolini, C. Bertucci, S. Dei, C. Ghelardini, M.G. Giovannini, F Gaultieri, G. Pepeu, S. Sepecchi and E. Teodori: Chirality 8, 225–233 (1996).

    Article  PubMed  CAS  Google Scholar 

  76. G.J. Sanger: Neurogastroenterol. Motil. 8, 319–331 (1996).

    Article  PubMed  CAS  Google Scholar 

  77. C.W. Hodge, J.S. Neihus and H.H. Samson: Psychopharmacol. 119, 186–192 (1995).

    Article  CAS  Google Scholar 

  78. I. Panocka, R. Ciccocioppo, C. Polodori, P. Pompei and M. Massi: Pharmacol. Bio-chem. Behav. 52, 255–259 (1995).

    Article  CAS  Google Scholar 

  79. C.M. Villalon, J.A. Terron, E. Ramirez-San Juan and P.R. Saxena: Arch. Med. Res., 26, 331–344 (1995).

    PubMed  CAS  Google Scholar 

  80. J.J. Lucas and R. Hen: Trends Pharmacol. Sci. 16, 246–252 (1995).

    Article  PubMed  CAS  Google Scholar 

  81. J. Bockaert, H. Ansanay, C. Waeber, M. Sebben, L. Fagni and A. Dumuis: CNS Drugs 7, 6–15 (1994).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurobiology Unit, Roche Bioscience, Center for Biological Research, 3401 Hillview Ave., Palo Alto, CA, 94304, USA

    Richard M. Eglen

Authors
  1. Richard M. Eglen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Steinweg 28, CH-4107, Ettingen, Switzerland

    Ernst Jucker

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Basel AG

About this chapter

Cite this chapter

Eglen, R.M. (1997). 5-Hydroxytryptamine (5-HT)4 receptors and central nervous system function: An update. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 49. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8863-9_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8863-9_1

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9807-2

  • Online ISBN: 978-3-0348-8863-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation