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Chemokines and eosinophils

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Chemokines and Skin

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Eosinophils (Eos) are recognized as proinflammatory cells implicated in protection against parasitic infection [1] and likely play a major role in allergic diseases such as bronchial asthma, and a number of dermatologic diseases including atopic dermatitis [2]–[4]. They can release from their granules several distinctive cationic proteins that have the potential to cause local tissue damage and dysfunction seen in many eosinophilic inflammatory skin diseases [1]. Specific cytoplasmic granules contain a unique crystalloid core composed of major basic protein (MBP), which is responsible for the cardinal tinctorial properties of the eosinophil [1]. In addition three other distinct cationic proteins, eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPO), which exert a range of biological effects on host cells and microbial targets, have been found in eosinophils [1].

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  1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105, Kiel, Germany

    Jens-M. Schröder

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  1. Abteilung für Experimentelle Dermatologie, Klinikum der Albert-Ludwigs-Universität, Hauptstr. 7, D-79104, Freiburg, Germany

    Eckhard Kownatzki  & Johannes Norgauer  & 

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Schröder, JM. (1998). Chemokines and eosinophils. In: Kownatzki, E., Norgauer, J. (eds) Chemokines and Skin. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8843-1_6

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  • DOI: https://doi.org/10.1007/978-3-0348-8843-1_6

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