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Genetic Models of Bacterial Lung Infection

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Molecular Biology of the Lung

Part of the book series: espiratory harmacology and harmacotherapy ((RPP))

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Abstract

The lung is a point of intimate contact of the host with its environment and as such is a key point of interaction between animals and microbes. A range of host defence mechanisms exists to protect the lung from infection. These defence mechanisms include physical defences such as the filtration of air and the mucociliary escalator as well as the innate immune mechanisms such as the alveolar macrophage. The activity of these cells is augmented by the presence of various opsonins within the lung, including complement components and immunoglobulins. The inflammatory response and specific immune response in the lung are controlled by a range of cytokines and other immune mediators. To cause disease an invading pathogen must be able to subvert these normal defences.

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  1. Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow, UK

    Timothy J. Mitchell

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  1. Department of Respiratory Medicine, University Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK

    Robert A. Stockley

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© 1999 Springer Basel AG

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Mitchell, T.J. (1999). Genetic Models of Bacterial Lung Infection. In: Stockley, R.A. (eds) Molecular Biology of the Lung. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8831-8_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8831-8_8

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9791-4

  • Online ISBN: 978-3-0348-8831-8

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