Abstract
The relationship between n-6 essential fatty acids (EFAs) and nervous system disorders is a subject of emerging interest. In one specific area, the peripheral neuropathy of diabetes, the role of n-6 EFAs is now well established. In other areas, including schizophrenia and dyskinesias, much less work has been done although there is tantalising evidence that n-6 EFAs may be involved. This review will primarily concentrate on diabetic neuropathy with a short section drawing attention to the few key papers in these disorders.
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References
Peifer JJ, Holman RT (1955) Essential fatty acids, diabetes and cholesterol. Arch Biochem Biophys 57: 520–521
Mercuri O, Peluffo RO, Brenner RR (1966) Depression of microsomal desaturation of linoleic to gamma-linolenic acid in the alloxan diabetic rat. Biochim Biophys Acta 116: 407–411
Brenner RR (1982) Nutritional and hormonal factors influencing desaturation of essen-tial fatty acids. Progr Lipid Res 20: 41–48
Horrobin DF (1992) Nutritional and medical importance of gamma-linolenic acid. Progr Lipid Res 31: 163–194
Horrobin DF (1988) The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus. Prostaglandins, Leukotr Essential Fatty Acids 31: 181–197
Horrobin DF (ed) (1992) Treatment of Diabetic Neuropathy: A New Approach. Churchill Livingstone, Edinburgh and New York
Jamal GA (1994) The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. Diabetic Med 11: 145–149
Horrobin DF, Durand LG, Manku MS (1977) Prostaglandin E1 modifies nerve conduc-tion and interferes with local anaesthetic action. Prostaglandins 14: 103–110
Julu POO (1988) Essential fatty acids prevent slowed nerve conduction velocity in strep-tozotocin diabetes rats. J Diabetic Comp 2: 185–188
Julu POO (1992) Responses of peripheral nerve conduction velocities to treatment with essential fatty acids in diabetic rats: possible mechanisms of action. In: DF Horrobin (ed): Treatment of diabetic neuropathy: a new approach. Churchill Livingstone, Edinburgh and New York, 41–62
Tomlinson DR, Robinson JP, Compton AM, Keen P (1989) Essential fatty acid treatment - effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats. Diabetologia 32: 655–659
Stevens EJ, Lockett MJ, Carrington AL, Tomlinson DR (1993) Essential fatty acids treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. Diabetologia 36: 397–401
Stevens EJ, Carrington AL, Tomlinson DR (1993) Prostacyclin release in experimental diabetes: effects of evening primrose oil. Prostaglandins Leukotr Essential Fatty Acids 49: 699–706
Cameron NE, Cotter MA, Robertson S (1991) Essential fatty acid diet supplementation. Effects on peripheral nerve and skeletal muscle function and capillarization in streptozocin-induced diabetic rats. Diabetes 40: 532–539
Dines KC, Cotter MA, Cameron NE (1993) Contrasting effects of treatment with ω-3 and ω-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. Diabetologia 36: 1132–1138
Cameron NE, Cotter MA (1993) Potential therapeutic approaches to the treatment or prevention of diabetic neuropathy: evidence from experimental studies. Diabetic Med 10: 593–605
Omawari N, Mahmood S, Dewhurst M, Stevens EJ, Tomlinson DR (1995) Deficient nitric oxide is responsible for reduced nerve blood flow in diabetic rats: prevention by essential fatty acids. Br J Pharmacol 116: 63
Redden PR, Lin XR, Fahey J, Horrobin DF (1995) Stereospecific analysis of the major triacylglycerol species containing gamma-linolenic acid in evening primrose oil and borage oil. J Chromatography 704: 99–111
Dines KC, Cameron NE, Cotter MA (1995) Comparison of the effects of evening primrose oil and triglycerides containing γ-linolenic acid on nerve conduction and blood flow in diabetic rats. J Pharmacol Exp Ther 273: 49–55
Dines KC Cotter MA, Cameron NE (1996) Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. Prostaglandins Leukotr Essent Fatty Acids 55: 159–165
Dines KC (1994) Effects of oils containing gamma-linolenic acid on nerve function in diabetic rats. PhD Thesis, University of Aberdeen
Jenkins DK, Mitchell JC, Manku MS, Horrobin, DF (1988) Effects of different sources of gamma-linolenic acid on the formation of essential fatty acid and prostanoid metabolites. Med Sci Res 16: 525–526
Fan Y-Y, Chapkin RS (1992) Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid. J Nutr 122: 1600–1606
Horrobin DF (1994) Natural does not equal safe. Pharmaceutical Tech Europe, December 14–15
Van Doormaal JJ, Idema IG, Muskiet FAJ, Martini IA, Doorenbos H (1988) Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, a-tocopherol levels, and erythropoiesis in normal and Type I (insulin-dependent) diabetic men. Diabetologia 31: 576–584
Tilvis RS, Miettinen TA (1985) Fatty acid composition of serum lipids erythrocytes and platelets in insulin-dependent diabetic women. J Clin Endocr Metabol 61: 741–745
Arisaka M, Arisaka O, Fukuda Y, Yamashiro Y (1986) Prostaglandin metabolism in children with diabetes mellitus. I. Plasma prostaglandin E2, F2a, TxB2 and serum fatty acid levels. J Paed Gastroenterol Nutr 5: 878–882
Horrobin DF (1997) Essential fatty acid metabolism in patients with diabetic neuropathy. Prostaglandins Leukotr EFAs 57: 256
Jamal GA, Carmichael H (1990) The effect of y linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. Diabetic Med 7: 319–323
The Gamma-linolenic Acid Multicenter Trial Group (1993) Treatment of diabetic neuropathy with y-linolenic acid. Diabetes Care 16: 8–15
Gamma-linolenic Acid Multicenter Trial Group (Boulton AJ) (1997) Two multicentre double blind trials of gamolenic acid in diabetic peripheral sensori motor neuropathy. Prostaglandins Leukotr EFAs 57: 201
Horrobin DF Glen AI, Vaddadi K (1994) The membrane hypothesis of schizophrenia. Schizophr Res 13: 195–207
Mahhadik SP, Gowda S (1996) Antioxidants in the treatment of schizophrenia. Drugs Today 32: 553–565
Ward P, Sutherland J, Glen E, Glen I (1998) Niacin skin flush in schizophrenia. Schizophr Res 29: 269–274
Nilsson A, Horrobin DF, Rosengren A, Waller L, Adlerberth A, Wilhelmsen L (1996) Essential fatty acids and abnormal involuntary movements in the general male population: a study of men born in 1933. Prostaglandins Leukotr EFAs 55: 83–87
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Horrobin, D.F. (1998). n-6 Fatty acids and nervous system disorders. In: Kremer, J.M. (eds) Medicinal Fatty Acids in Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8825-7_5
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DOI: https://doi.org/10.1007/978-3-0348-8825-7_5
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9788-4
Online ISBN: 978-3-0348-8825-7
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