Skip to main content
SpringerLink
Log in

Adhesion molecules in arthritis: Control of T cell migration into the synovium

  • Chapter
T Cells in Arthritis

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory condition that affects approximately 0.8% of the world population [1,2]. Although there are frequent systemic manifestations of inflammation, the primary physiological events occur within the synovial tissue lining of diarthrodial joints. In spite of intense investigation, the cause of RA and the precise pathophysiological events remain uncertain. Much attention has focused on T lymphocytes and the role they play in the pathogenesis of RA. Along with functional analyses of T cell populations, the mechanisms by which T cells enter rheumatoid synovium has been the focus of considerable investigation. A number of studies have demonstrated an essential role for cell surface adhesion receptors in T cell migration, although the specific receptors employed by T cells and their counterreceptors on endothelial cells have not been completely delineated. Postcapillary venules appear to be the site of T cell entry into the synovium, although this conclusion is based more on analogy to other tissue sites rather than direct experimental verification in the synovium.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lipsky PE (1997) Rheumatoid Arthritis. In: AS Fauci, E Braunwald, KJ Isselbacher, JD Wilson, JB Martin, DL Kasper, SL Hauser and DL Longo (eds): Harrison’s Principles of Internal Medicine, 14th edition. New York: McGraw Hill, 1880–1888

    Google Scholar 

  2. Harris ED (ed) (1997) Reumatoid Arthritis. Philadelphia: W.B. Saunders

    Google Scholar 

  3. Van Boxel JA, Paget SA (1975) Predominantly T cell infiltrate in rheumatoid synovial membranes. N Engl J Med 293: 517–520

    PubMed  Google Scholar 

  4. Janossy G, Panay GS, Duke O, Bofill M, Poulter LW, Goldstein G (1981) Rheumatoid arthritis: a disease of T lymphocyte/macrophage immunoregulation. Lancet 2: 839–842

    PubMed  CAS  Google Scholar 

  5. Kurosaka M, Ziff M (1983) Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med 158: 1191–210

    PubMed  CAS  Google Scholar 

  6. Cush JJ, Lipsky PE (1988) Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 31: 1230–1238

    PubMed  CAS  Google Scholar 

  7. Stastny P (1978) Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 298: 869–871

    PubMed  CAS  Google Scholar 

  8. Lipsky PE, Davis LS, Cush JJ, Oppenheimer-Marks N (1989) The role of cytokines in the pathogenesis of rheumatoid arthritis. Springer Semin Immunopathol 11: 123–162

    PubMed  CAS  Google Scholar 

  9. Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Ann Rev Immunol 14: 397–440

    CAS  Google Scholar 

  10. Koch AE, Kunkel SL, Strieter RM (1995): Cytokines in rheumatoid arthritis. J Invest Med 43: 28–38

    CAS  Google Scholar 

  11. Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, Zvaifler NJ (1988) Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (IL-2 and IL-3) and presence of macrophage colony-stimulating factor (CSF1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med 168: 1573–1586

    PubMed  CAS  Google Scholar 

  12. Firestein GS, AlvaroGarcia JM, Maki R (1990) Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 144: 3347–3353

    PubMed  CAS  Google Scholar 

  13. Simon AK, Seipelt E, Sieper J (1994) Divergent T-cell cytokine patterns in inflammatory arthritis. Proc Natl Acad Sci USA 91: 8562–8566

    PubMed  CAS  Google Scholar 

  14. Brennan FM, Field M, Chu CQ, Feldmann M, Maini RN (1991) Cytokine expression in rheumatoid arthritis. Brit J Rheumatol 30: (suppl 1): 76–80

    Google Scholar 

  15. Dolhain RJEM, van der Heiden AN, ter Haar NT, Breedveld FC, Miltenburg AMM (1997) Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 39: 1961–1969

    Google Scholar 

  16. Isomäki P, Luukkainen R, Toivanen P, Punnonen J (1996) The presence of interleukin13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. Arthritis Rheum 39: 1693–1702

    PubMed  Google Scholar 

  17. Kotake S, Schumacher Jr HR, Yarboro CH, Arayssi TK, Pando JA, Kanik KS, Gourley MF, Klippel JH, Wilder RL (1997) In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients with early stages of rheumatoid, reactive, and undifferentiated arthritis. Proc Assn Amer Phy 109: 286–301

    CAS  Google Scholar 

  18. Bucht A, Larsson P, Weisbrot L, Thorne C, Pisa P, Smedegard G, Keystone EC, Grönberg (1996) Expression of interferon-gamma (IFN-), IL-10, IL-12 and transforming growth factor-beta (TGF-) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA). Clin Exp Immunol 103: 357–367

    PubMed  CAS  Google Scholar 

  19. Wagner AD, Bjornsson J, Bartley GB, Goronzy JJ, Weyand CM (1996) Interferon gamma producing T cells in giant cell vasculitis represent a minority of tissue infiltrating cells and are located distant from the site of pathology. Amer J Pathol 148: 1925–1933

    CAS  Google Scholar 

  20. Maurice MM, Nakamura J, van der Voort EAM, van Vliet AI, Staal FJT, Tak PP, Breedveld FC, Verweij CL (1997) Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. J Immunol 158: 1458–1465

    PubMed  CAS  Google Scholar 

  21. Maurice MM, Lankester AC, Bezemer AC, Geertsma MF, Tak PP, Breedveld FC, van Lier RAW Verweij CL (1997) Defective TCR-medicated signaling in synovial T cells in rheumatoid arthritis. J Immunol 159: 2973–2978

    PubMed  CAS  Google Scholar 

  22. Thomas R, Mcllraith M, Davis L, Lipsky PE (1992) Rheumatoid synovium is enriched in CD45RBdim memory T cells that are potent helpers for B cell differentiation. Arthritis Rheum 35: 1455–1465

    PubMed  CAS  Google Scholar 

  23. Cush JJ, Lipsky PE (1988) Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 31: 1230–1238

    PubMed  CAS  Google Scholar 

  24. Kohem CL, Brezinschek RI, Wisbey H, Tortorella C, Lipsky PE, Oppenheimer-Marks N (1996) Enrichment of differentiated CD45RBdim, CD27-memory T cells in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 39: 844–854

    PubMed  CAS  Google Scholar 

  25. Hemler ME, Glass D, Coblyn JS, Jacobson JG (1986) Very late activation antigens on rheumatoid synovial T lymphocytes. Association with stages of T cell activation. J Clin Invest 78: 696–702

    PubMed  CAS  Google Scholar 

  26. Takahashi H, Söderström K, Nilsson E, Kiessling R, Patarroyo M (1992) Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients. Eur J Immunol 22: 2879–2885

    PubMed  CAS  Google Scholar 

  27. Afeltra A, Galeazzi M, Ferri GM, Amoroso A, De Pita O, Porzio F, Bonomo L (1993) Expression of CD69 antigen on synovial fluid T cells in patients with thrumatoid arthritis and chronic synovitis. Ann Rheum Dis 52: 457–460

    PubMed  CAS  Google Scholar 

  28. Laffon A, Garcia Vicuna R, Humbria A, Postigo AA, Corbi AL, de Landazuri MO, Sanchez Madrid F (1991) Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J Clin Invest 88: 546–552

    PubMed  CAS  Google Scholar 

  29. Sfikakis PP, Zografou A, Viglis V, Iniotaki-Theodoraki A, Piskontaki I, Tsokos GC, Sfikakis P, Choremi-Papadopoulou H (1995) CD28 expression on T cell subsets in vivo and CD28-mediated T cell response in vitro in patients with rheumatoid arthritis. Arthritis Rheum 38: 649–644

    PubMed  CAS  Google Scholar 

  30. Kelleher D, Murphy A, Hall Nicola, Omary MB, Kearns G, Long A Casey EB (1995) Expression of CD44 on rheumatoid synovial fluid lymphocytes. Ann Rheum Dis 54: 566–570

    PubMed  CAS  Google Scholar 

  31. Yokota A, Murata N, Saiki O, Shimizu M, Springer TA Kishimoto T (1995) High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes. J Immunol 155: 4118–4124

    PubMed  CAS  Google Scholar 

  32. Isomäki P, Aversa G, Cocks BG, Luukkainen R, Saario R, Toivanen P, de Vries JE, Punnonen J (1997) Increased expression of signaling lymphocytic activation molecule in patients with rheumatoid arthritis and its role in the regulation of cytokine production in rheumatoid synovium. J Immunol 159: 2986–2993

    PubMed  Google Scholar 

  33. MacDonald KPA, Nishioka Y, Lipsky PE, Thomas R (1997) Functional CD40 ligand is expressed by T cells in rheumatoid arthritis. J Clin Invest 100: 2404–2414

    PubMed  CAS  Google Scholar 

  34. Tortorella C, Schulze-Koops H, Thomas R, Splawski JB, Davis LS, Picker LJ, Lipsky PE (1995) Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation. J Immunol 155: 149–162

    CAS  Google Scholar 

  35. Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS (1995) Elevated Th1 or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol 155: 5029–5037

    PubMed  CAS  Google Scholar 

  36. Brezinschek RI, Lipsky PE, Galea P, Vita R, Oppenheimer-Marks N (1995) Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity. J Immunol 154: 3062–3077

    PubMed  CAS  Google Scholar 

  37. Jalkanen S, Steere AC, Fox RI, Butcher EC (1986) A distinct endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium. Science 233: 556–558

    PubMed  CAS  Google Scholar 

  38. Oppenheimer-Marks N, Ziff M (1986) Binding of normal human mononuclear cells to blood vessels in rheumatoid arthritis synovial membrane. Arthritis Rheum 29: 789–792

    PubMed  CAS  Google Scholar 

  39. Kavanaugh AF, Oppenheimer-Marks N (1992) The role of the endothelium in the pathogenesis of vasculitis. In: EC LeRoy (ed): Systemic Vasculitis: The Biological Basis New York: Marcel Dekker, Inc 27–48

    Google Scholar 

  40. Freemont AJ (1987) Molecules controlling lymphocyte-endothelial interactions in lymph nodes are produced in vessels in inflamed synovium. Ann Rheum Dis 4: 924–928

    Google Scholar 

  41. Freemont AJ, Jones CJP, Bromley M, Andrews P (1983) Changes in vascular endothelium related to lymphocyte collections in diseased synovia. Arthritis Rheum 26: 1427–1433

    PubMed  CAS  Google Scholar 

  42. Iguchi T, Ziff M (1986) Electron microscopic study of rheumatoid synovial vasculature. J Clin Invest 77: 355–361

    PubMed  CAS  Google Scholar 

  43. Yanni G, Whelan, A, Feighery, C, Fitzgerald, O, Bresnihan, B (1993) Morphometric analysis of synovial membrane blood vessels in rheumatoid arthritis: Associations with the immunohistologic features, synovial fluid, cytokine levels and the clinical course. J Rheum 20: 634–638

    PubMed  CAS  Google Scholar 

  44. Picker LJ, Siegelman MH (1993) Lymphoid tissues and organs. In: Paul, WE (ed): Fundamental Immunology 3rd edn. New York: Raven Press. 145–197

    Google Scholar 

  45. Ziff M, Iguchi T (1987) Electron microscopic study of rheumatoid synovial vasculature: Intimate relationship between tall endothelium and lymphoid aggregation. Int. J. Tissue Reactions 9: 273–276

    CAS  Google Scholar 

  46. Munro JM, Pober JS, Cotran RS (1989) Tumor necrosis factor and interferon-induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio Anubis. Am J Path 135: 121–133

    PubMed  CAS  Google Scholar 

  47. Fossum S, Smith ME, Ford WL (1983). The recirculation of T and B lymphocytes in the athymic, nude rat. Scand. J. Immunol. 17: 551–557

    CAS  Google Scholar 

  48. Oppenheimer-Marks N, Lipsky, PE (1994) Transendothelial migration of T cells in chronic inflammation. The Immunologist 2: 58–64

    Google Scholar 

  49. Hale LP, Martin ME, McCollum DE, Nunley JA, Springer TA, Singer KH, Haynes BF (1989) Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum 32: 22–30

    PubMed  CAS  Google Scholar 

  50. Koch A, Burrows JC, Haines GK, Carlos TM, Harlan JM, Leibovich SJ (1991) Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissue. Lab Invest 64, 313–320

    PubMed  CAS  Google Scholar 

  51. Tak PP, Thurkow EW, Daha MR, Kluin PM, Smeets TJ, Meinders AE, Breedveld FC (1995) Expression of adhesion molecules in early rheumatoid synovial tissue. Clin Immunol Immunopathol 77: 236–242

    PubMed  CAS  Google Scholar 

  52. Grober JS, Bowen BL, Ebling H, Athey B, Thompson CB, Fox DA, Stoolman LM (1993) Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin dependent interactions. J Clin Invest 91, 2609–2619

    PubMed  CAS  Google Scholar 

  53. Yousseff PP, Triantafillou S, Parker A, Coleman M, Roberts-Thomson PJ, Ahern MJ, Smith MD (1997) Variability in cytokine and cell adhesion molecule staining in arthroscopie synovial biopsies: quantification using color video image analysis. J Rheumatol 24: 2291–2298

    Google Scholar 

  54. Geiger B, Ayalon O (1992) Cadherins Annu Rev Cell Biol 8: 307–332

    CAS  Google Scholar 

  55. Salmi M, Kalimo K, Jalkanen S (1993) Induction and function of vascular adhesion protein-1 at sites of inflammation. J Exp Med 178: 2255–2260

    PubMed  CAS  Google Scholar 

  56. Salmi M, Jalkanen S (1996) Human vascular adhesion protein 1 (VAP-1) is a unique sialoglycoprotein that mediates carbohydrate-dependent binding of lymphocytes to endothelial cells. J Exp med 183: 569–579

    PubMed  CAS  Google Scholar 

  57. Friedlander M, Brooks PC, Schaffer RW, Kincaid CM, Varner JA, Cheresh DA (1995) Definition of two angiogenic pathways by distinct V integrins. Science 270: 1500–1502

    PubMed  CAS  Google Scholar 

  58. Oppenheimer-Marks N, Lipsky PE (1997) Adhesion molecules and the regulation of the migration of lymphocytes. In: A Hamann (ed): Adhesion Molecules and Chemokines in Lymphocyte Trafficking. The Netherlands: Harwood Academic Publishers 55–88

    Google Scholar 

  59. van Dinther-Janssen AC, Horst E, Koopman G, Newmann W, Scheper RJ, Meijer CJ, Pals ST (1991) The VLA-4IVCAM-1 pathway is involved in lymphocyte adheison to endothelium n rheumatoid synovium. J Immunol 147: 4207–4210

    PubMed  Google Scholar 

  60. Oppenheimer-Marks N, Davis LS, Lipsky PE (1990) Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell. J Immunol 145: 140–148

    PubMed  CAS  Google Scholar 

  61. Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 425–434

    PubMed  CAS  Google Scholar 

  62. Tanaka Y, Albelda SM, Horgan KJ, van Seventer GA, Shimizu Y, Newman W, Hallam J, Newman PJ, Buck CA, Shaw S (1992) CD31 expressed on distinctive T cell subsets is a preferential amplifier of 1 integrin-mediated adhesion. J Exp Med 176: 245–253

    CAS  Google Scholar 

  63. Oppenheimer-Marks N, Brezinschek RI, Mohamadzadeh M, Vita R, Lipsky PE (1998) Interleukin-15 is produced by endothelial cells and increases the transendothelial migration of T cells in vitro and in the SCDI mouse-human rheumatoid arthritis model in vivo. J Clin Invest 101: 1261–1272

    CAS  Google Scholar 

  64. Altmann DM, Hogg N, Trowsdale J, Wilkinson D (1989) Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells. Nature 338: 512–514

    PubMed  CAS  Google Scholar 

  65. Davis LS, Oppenheimer-Marks N, Bednarczyk JL, McIntyre BW, Lipsky PE (1990) Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules. J Immunol 145: 785–793

    PubMed  CAS  Google Scholar 

  66. Shimizu Y, van Seventer GA, Horgan KJ, Shaw S (1990) Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J. Immunol 145: 59–67

    PubMed  CAS  Google Scholar 

  67. van Seventer GA, Shimizu Y, Horgan KJ, Shaw S (1990) The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J Immunol 144: 4579–4586

    PubMed  Google Scholar 

  68. van Seventer GA, Newman W, Shimizu Y, Nutman TB, Tanaka Y, Horgan KJ, Gopal TV, Ennis E, O’Sullivan D, Grey H, Shaw S (1991) Analysis of T cell stimulation by super-antigen plus major histocompatability complex class II molecules or by CD3 monoclonal antibody: Costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1. J Exp Med 174: 901–913

    PubMed  Google Scholar 

  69. Damle NK, Klussman K, Leytze G, Ochs HD, Aruffo A, Linsley PS, Ledbetter JA (1993) Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7. Cell Immunol 148: 144–156

    PubMed  CAS  Google Scholar 

  70. Kavanaugh AF, Davis LS, Nichols LA, Norris SH, Rothlein R, Scharschmidt LA, Lipsky PE (1992) Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule-1. Arthritis Rheum 37: 992–999.

    Google Scholar 

  71. Paleolog EM, Hunt M, Elliott MJ, Feldmann M, Maini RN, Woody JN (1996) Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis. Arthritis Rheum 39: 1082–1091

    PubMed  CAS  Google Scholar 

  72. Lawrence MB, Springer, TA (1991) Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins. Cell 65: 859–873

    PubMed  CAS  Google Scholar 

  73. Butcher EC (1991) Leukocyte-endothelial cell recognition: Three (or more) steps for specificity and diversity. Cell 67: 1033–1036

    PubMed  CAS  Google Scholar 

  74. Picker LJ, Warnock RA, Burns AR, Doerschuk CM, Berg EL, Butcher EC (1991) The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 66: 921–933

    PubMed  CAS  Google Scholar 

  75. Kishimoto TK, Warnock RA, Jutila MA, Butcher EC, Lane C, Anderson DC, Smith CW (1991) Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/Dreg 56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78: 805–811

    CAS  Google Scholar 

  76. Huber AR, Kunkel SL, Todd III RF, Weiss SJ (1991) Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 254: 99–102

    PubMed  CAS  Google Scholar 

  77. Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Rudloff HE, Schmalsteig FC, Anderson DC (1988) Recognition of an endothelial determinant for CD18-dependent human neutrophil adherence and transendothelial migration. J Clin Invest 82: 1746–1756

    PubMed  CAS  Google Scholar 

  78. Smith WC, Marlin SD, Rothlein R, Toman C, Anderson DC (1989) Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 83: 2008–2017

    CAS  Google Scholar 

  79. Muller WA, Weigel SA, Deng X, Phillips DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178: 449–460

    PubMed  CAS  Google Scholar 

  80. Kansas GS, Spertini O, Stoolman LM, Tedder TF (1991) Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. J Cell Biol 114: 351–358

    PubMed  CAS  Google Scholar 

  81. Lasky LA, Singer MS, Yednock TA, Dowbenko D, Fennie C, Rodriguez H, Nguyen T, Stachel S, Rosen SD (1989) Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell 56: 1045–1055

    PubMed  CAS  Google Scholar 

  82. Masumoto A, Hemler ME (1993) Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem 268: 228–234

    PubMed  CAS  Google Scholar 

  83. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA (1995) The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 128: 1243–1252.

    PubMed  CAS  Google Scholar 

  84. Lalor PF, Clements JM, Pigott R, Humphries MJ, Spragg JH, Nash GB (1997) Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1. Eur J Immunol 27: 1442–1426

    Google Scholar 

  85. Berg EL, Robinson MK, Warnock RA, Butcher EC (1991) The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J Cell Biol 114: 343–349

    PubMed  CAS  Google Scholar 

  86. Kotovouri P, Tontti E, Pigott R, Shepard M, Kiso M, Hasegawa A, Renkonen R, Nor-tamo P, Altieri DC, Gahmberg CG (1993) The vascular E-selectin binds to the leukocyte integrins CD11/CD18. Glycobiology 3: 131–136

    Google Scholar 

  87. Sako D, Chang XJ, Barone KM, Vachino G, White HM, Shaw G, Veldman GM, Bean KM, Ahern TJ, Furie B, et al (1993) Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75: 1179–1186.

    PubMed  CAS  Google Scholar 

  88. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS (1997) Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389: 978–981

    PubMed  CAS  Google Scholar 

  89. Galea P, Brezinschek R, Lipsky PE, Oppenheimer-Marks N (1994) Phenotypic characterizatin of CD4(-)/ TCR(+) and TCR(+) T cells with a transendothelial migratory capacity. J Immunol 153: 529–542

    PubMed  CAS  Google Scholar 

  90. Baggiolini M, Dewald B, Moser B (1997) Human chemokines: An update. Annu Rev Immunol 15: 675–705

    PubMed  CAS  Google Scholar 

  91. Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ et al (1994) Lymphotactin: A cytokine that represents a new class of chemokine. Science 266: 1395–1399

    PubMed  CAS  Google Scholar 

  92. Timothy N, Wells C, Peitsch MC (1997) The chemokine information source: identification and characterization of novel chemokines using the World Wide Web and Expressed Sequence Tag Databases (1997) J Leuk Biol 61: 545–550

    Google Scholar 

  93. Baggiolini M, Dewald D, Moser B (1994) Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines. Adv Immunol 55: 97–179

    PubMed  CAS  Google Scholar 

  94. Benbaruch A, Michiel DF, Oppenheim JJ (1995) Signals and receptors involved in recruitment of inflammatory cells. J Biol Chem 270: 11703–11706

    CAS  Google Scholar 

  95. Brennan FM, Zachariae COC, Chantry D, Larsen CG, Turner M, Maini RN, Matsushima K, Feldmann M (1990) Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. Eur J Immunol 20: 2141–2144

    PubMed  CAS  Google Scholar 

  96. Schall TJ, Bacon K, Toy K.J, Goeddel DV (1990) Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347: 669–671

    PubMed  CAS  Google Scholar 

  97. Lipes MA, Napolitano M, Jeang K-T, Chang NT, Leonard WJ (1988) Identification, cloning, and characterization of an immune activation gene. Proc Natl Acad Sci USA 85: 9704–9708

    PubMed  CAS  Google Scholar 

  98. Schall TJ, Bacon K, Camp RDR, Kaspari JW, Goeddel DV (1993) Human macrophage inflammatory protein-1 (MIP-1) and MIP-1 chemokines attract distinct populations of lymphocytes. J Exp Med 177: 1821–1825

    PubMed  CAS  Google Scholar 

  99. Rathanaswami P, Hachicha M, Sadick M, Schall TJ, McColl SR (1993) Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. J Biol Chem 268: 5834–5839

    PubMed  CAS  Google Scholar 

  100. Streiter RM, Polverini PJ, Arenberg DA, Kunkel SL (1995) The role of CXC chemokines as regulators of angiogenesis. Shock 4: 155–160

    Google Scholar 

  101. Streiter RM, Polverini PJ, Kunkel SL (1995) The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 270: 27348–27357

    Google Scholar 

  102. Ebnet K, Kaldijian EP, Anderson AO, Shaw S (1996) Orchestrated information transfer underlying leukocyte endothelial interactions. Annu Rev Immunol 14: 155–177

    PubMed  CAS  Google Scholar 

  103. Wilkinson PC, Liew FY (1995) Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181: 1255–1259

    PubMed  CAS  Google Scholar 

  104. McInnis IB, Al-Mughales J, Field M, Leung BP, Huang F-P, Dixon R, Sturrock RD, Wilkinson PC, Liew FY (1996) The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nature Med 2: 175–182

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rheumatic Diseases Division of The Department of Internal Medicine, The University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX, 75235-3577, USA

    Nancy Oppenheimer-Marks & Peter E. Lipsky

Authors
  1. Nancy Oppenheimer-Marks
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter E. Lipsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departments of Immunology and Rheumatology HĂ´pital Edouard Herriot, University Claude Bernard, Lyon Cedex 03, F-69437, France

    Pierre Miossec

  2. Division of Rheumatology, UCSD School of Medicine, 9500 Gilman Drive, San Diego, CA, 92093-0656, USA

    Gary S. Firestein

  3. Department of Rheumatology, University Hospital Nijmegen, Geert Grooteplein 8, Nijmegen, NL-6525, The Netherlands

    Wim B. van den Berg

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Basel AG

About this chapter

Cite this chapter

Oppenheimer-Marks, N., Lipsky, P.E. (1998). Adhesion molecules in arthritis: Control of T cell migration into the synovium. In: Miossec, P., Firestein, G.S., van den Berg, W.B. (eds) T Cells in Arthritis. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8823-3_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8823-3_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9787-7

  • Online ISBN: 978-3-0348-8823-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation