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Endothelin in Lung Development and Tissue Growth

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Pulmonary Actions of the Endothelins

Abstract

Endothelins (ETs), a family of polypeptides with a wide range of activities in the airways and pulmonary vascular system, are synthesized by respiratory epithelium and by pulmonary vascular endothelium [1–4].

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References

  1. Black PN, Ghatei MA, Takahashi K et al (1989) Formation of endothelin by cultured airway epithelial cells. FEBS Lett 255: 129–132

    Article  PubMed  CAS  Google Scholar 

  2. Rozengurt N, Springall DR, Polak JM (1990) Localization of endothelin-like immunoreactivity in airway epithelium of rats and mice. J Pathol 160: 5–8

    Article  PubMed  CAS  Google Scholar 

  3. Rubanyi GM, Polokoff MA (1994) Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacological Reviews 46: 325–415

    PubMed  CAS  Google Scholar 

  4. Giaid G, Polak JM, Gaitonde V et al (1991) Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult lung. Am J Respir Cell Mol Biol 4: 50–58

    PubMed  CAS  Google Scholar 

  5. Nunez DJR, Brown MJ, Davenport AP, Neylon CB, Schofield JP, Wyse RK (1990) Endothelin-1 mRNA is widely expressed in porcine and human tissues. J Clin Invest 85: 1537–1541

    Article  PubMed  CAS  Google Scholar 

  6. MacCumber MW, Ross CA, Glaser BM, Snyder SH (1989) Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action. Proc Natl Acad Sci USA 86: 7285–7289

    Article  PubMed  CAS  Google Scholar 

  7. Mattoli S, Mezzetti M, Riva G, Allegra L, Fasoli A (1990) Specific binding of endothelin on human bronchial smooth muscle cells in culture and secretion of endothelin like material from bronchial epithelial cells. Am J Respir Cell Mol Biol 3: 145–151

    PubMed  CAS  Google Scholar 

  8. Endo T, Uchida Y, Matsumoto H et al (1992) Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines. Biochem Biophys Res Com 186: 1594–1599

    Article  PubMed  CAS  Google Scholar 

  9. White SR, Hathaway DP, Umans JG, Leff AR (1992) Direct effects on airway smooth muscle contractile response caused by endothelin pig trachealis. Am Rev of Respir Dis 145: 491–493

    CAS  Google Scholar 

  10. Arai H, Hori S, Aramori I, Ohkubo H Nakanishi S (1990) Cloning and expression of a cDNA encoding an endothelin receptor. Nature 348: 730–732

    Article  PubMed  CAS  Google Scholar 

  11. Sakurai M, Yanagisawa M, Takuwa Y et al (1990) Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature 348: 732–735

    Article  PubMed  CAS  Google Scholar 

  12. Gariepy CE, Cass DT, Yanagisawa M (1996) Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proc Natl Acad Sci USA 93: 867–872

    Article  PubMed  CAS  Google Scholar 

  13. Power RF, Wharton J, Zhao Y, Bloom SR, Polak JM (1989) Autoradiographic localization of endothelin-1 binding sites in the cardiovascular and respiratory systems. J Cardiovasc Pharmacol 13 (Suppl 5): S50–S56

    Article  PubMed  CAS  Google Scholar 

  14. Henry PJ, Rigby PJ, Self GJ, Preuss JM, Goldie RG (1990) Relationship between endothelin-1 binding site densities and constrictor activities in human and animal airway smooth muscle. Brit J Pharmacol 100: 786–792

    CAS  Google Scholar 

  15. Hemsen A, Franco-Cereceda A, Matran R, Rudehill A, Lundberg JM (1990) Occurrence, specific binding sites and functional effects of endothelin in human cardiopulmonary tissue. Eur J Pharmacol 191: 319–328

    Article  PubMed  CAS  Google Scholar 

  16. Goldie RG, D’Aprile AC, Self GJ, Rigby PJ, Henry PJ (1996) The distribution and density of receptor subtypes for endothelin-1 in peripheral lung of the rat, guinea-pig and pig. Brit J Pharmacol 117: 729–735

    CAS  Google Scholar 

  17. Kurihara Y, Kurihara H, Suzuki H et al (1994) Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 368: 703–710

    Article  PubMed  CAS  Google Scholar 

  18. Kurihara Y, Kurihara H, Oda H et al (1995) Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 96: 293–300

    Article  PubMed  CAS  Google Scholar 

  19. Maemura K, Kurihara H, Kurihara Y, Nagai R, Yazaki Y (1994) Isolation and characterization of vascular endothelial cells derived from mice lacking endothelin-1. Biochem Biophys Res Com 201: 538–545

    Article  PubMed  CAS  Google Scholar 

  20. Maemura K, Kurihara H, Kurihara Y, Kuwaki T, Kumada M, Yazaki Y (1995) Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice. J Cardiovasc Pharmacol 26 (Suppl 3): S17–S21

    PubMed  CAS  Google Scholar 

  21. Hocher B, Thone-Reineke C, Rohmeiss P et al (1997) Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest 99: 1380–1389

    Article  PubMed  CAS  Google Scholar 

  22. Baynash AG, Hosoda K, Giaid A et al (1994) Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 79: 1277–1285

    Article  PubMed  CAS  Google Scholar 

  23. Hosoda K, Hammer RE, Richardson JA et al (1994) Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 79: 1267–1276

    Article  PubMed  CAS  Google Scholar 

  24. Amiel J, Attie T, Jan D et al (1996) Heterogeneous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease. Human Molecular Genetics 5: 355–357

    Article  PubMed  CAS  Google Scholar 

  25. Nataf V, Lecoin L, Eichmann A, Le Douarin NM (1996) Endothelin-B receptor is expressed by neural crest cells in the avian embryo. Proc Natl Acad Sci USA 93: 9645–9650

    Article  PubMed  CAS  Google Scholar 

  26. Lahav R, Ziller C, Dupin E, Le Douarin NM (1996) Endothelin 3 promotes neural chest cell proliferation and mediates a vast increase in melanocyte number in culture. Proc Natl Acad Sci USA 93: 3892–3897

    Article  PubMed  CAS  Google Scholar 

  27. Chan TS, Lin CX, Chan SS, Chung SK (1995) Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development. Eur J Biochem 234: 819–826

    Article  PubMed  CAS  Google Scholar 

  28. Guembe L, Villaro AC, Bodegas ME (1996) Immunocytochemical detection of endothelin during the development of murine lung. Internatl J Dev Biol (Suppl 1): 257S–258S

    Google Scholar 

  29. Loesch A, Burnstock G (1996) Ultrastructural localization of nitric oxide synthase and endothelin in rat pulmonary artery and vein during postnatal development and aging. Cell and Tissue Research 283: 355–365

    Article  PubMed  CAS  Google Scholar 

  30. Grunstein MM, Rosenberg SM, Schramm CM, Pawlowski NA (1991) Mechanisms of action of endothelin 1 in maturing rabbit smooth muscle. Am J Physiol 260: L434–L443

    PubMed  CAS  Google Scholar 

  31. Mavquin-Mavier I, Levame M, Istin N, Harf A (1989) Mechanisms of endothelin mediated bronchoconstriction in the guinea pig. J Pharmacol Exp Ther 250: 740–745

    Google Scholar 

  32. Uchida Y, Ninomiya H, Saotome M et al (1988) Fndothelin, a novel vasoconstrictor peptide as potent bronchoconstrictor. Eur J Pharmacol 154: 227–228

    Article  PubMed  CAS  Google Scholar 

  33. Maggi CA, Patacchini R, Giuliani S, Meli A (1989) Potent contractile effect of endothelin in isolated guinea-pig airways. Eur J Pharmacol 160: 179–182

    Article  PubMed  CAS  Google Scholar 

  34. Hay DWP, Henry PJ, Goldie RG (1993) Endothelin and the respiratory system. Trends Pharmacol Sci 14: 29–32

    Article  PubMed  CAS  Google Scholar 

  35. White SR, Hathaway DP, Umans JG, Tallet J, Abrahams C, Leff AR (1991) Epithelial modulation of airway smooth muscle response to endothelin-1. Am Rev of Respir Dis 144: 373–378

    Article  CAS  Google Scholar 

  36. Plews PI, Abdel-Malek ZA, Doupnik CA, Leikauf GD (1991) Endothelin stimulates chloride secretion across canine tracheal epithelium. Am J Physiol 261: L188–L194

    PubMed  CAS  Google Scholar 

  37. Eguchi S, Hirata Y, Ihara M, Yano M, Marumo F (1992) A novel ETA antagonist (BQ 123) inhibits endothelin 1 induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells. FEBS Lett 302: 243–246

    Article  PubMed  CAS  Google Scholar 

  38. Bialecki RA, Izzo NJ jr, Colucci WS (1989) Endothelin 1 increases intracellular calcium mobilization but not calcium uptake in rabbit vascular smooth muscle cells. Biochem Biophys Res Com 164: 474–479

    Article  PubMed  CAS  Google Scholar 

  39. Kai H, Kanaide H, Nakamura M (1989) Endothelin sensitive intracellular Ca2+ store overlaps with caffeine sensitive one in rat aortic smooth muscle cells in primary cultures. Biochem Biophys Res Com 158: 235–243

    Article  PubMed  CAS  Google Scholar 

  40. Lee TS, Chao T, Hu KO, King GL (1989) Endothelin stimulates a sustained 1,2 diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells. Biochem Biophys Res Com 162: 381–386

    Article  PubMed  CAS  Google Scholar 

  41. Griendling KK, Tsuda T, Alexander RW (1989) Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells. J Biol Chem 264: 8237–8240

    PubMed  CAS  Google Scholar 

  42. Resink TJ, Scott-Burden T, Buhler FR (1990) Activation of multiple signal transduction pathways by endothelin in cultured human vascular smooth muscle cells. Eur J Biochem 189: 415–421

    Article  PubMed  CAS  Google Scholar 

  43. De Nucci G, Thomas R, D’Orleans Juste P et al (1988) Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium derived relaxing factor. Proc Natl Acad Sci USA 85: 9797–9800

    Article  PubMed  Google Scholar 

  44. Grunstein MM, Chuang ST, Schramm CM, Pawlowski NA (1991) Role of endothelin 1 in regulating rabbit airway contractility. Am J Physiol 260: L75–L82

    PubMed  CAS  Google Scholar 

  45. Resink TJ, Scott-Burden T, Buhler FR (1989) Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells. Biochem Biophys Res Com 158: 279–286

    Article  PubMed  CAS  Google Scholar 

  46. Schumacher WA, Steinbacher TE, Allen GT, Ogletree ML (1990) Role of thromboxane receptor activation in the bronchospasmic response to endothelin. Prostaglandins 40: 71–79

    Article  PubMed  CAS  Google Scholar 

  47. Bobik A, Grooms A, Millar JA, Mitchell A, Grinpukel S (1990) Growth factor activity of endothelin on vascular smooth muscle. Am J Physiol 258: C408–C415

    PubMed  CAS  Google Scholar 

  48. Takimoto M, Oda K, Fruh T, Takai M, Okada T, Sasaki Y (1996) ETA and ETB receptors cooperate in DNA synthesis via opposing regulations of cAMP in human lung cell line. Am J Physiol 271 (3, Pt 1): L366–L373

    PubMed  CAS  Google Scholar 

  49. Janakidevi K, Fisher MA, Del Veccio PJ, Tirappathi C, Figge J, Malik AB (1992) Endothelin 1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells. Am J Physiol 263: C1295–C1301

    PubMed  CAS  Google Scholar 

  50. Panettieri RA, Goldie RG, Rigby PJ, Eszterhas AJ, Hay DWP (1996) Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon. Brit J Pharmacol 118: 191–197

    CAS  Google Scholar 

  51. Simonson MS, Herman WH (1993) Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. J Biol Chem 268: 9347–9357

    PubMed  CAS  Google Scholar 

  52. Ricagna F, Miller VM, Tazelaar HD, McGregor CG (1996) Endothelin-1 and cell proliferation in lung organ cultures. Implications for lung allografts. Transplantation 62: 1492–1498

    Article  PubMed  CAS  Google Scholar 

  53. Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ (1997) Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. J Biol Chem 272: 17734–17743

    Article  PubMed  CAS  Google Scholar 

  54. Wang Y, Rose PM, Webb ML, Dunn MY (1994) Endothelins stimulate mitogen-activated protein kinase cascade through either ETA or ETB. Am J Physiol 267: C1130–C1135

    PubMed  CAS  Google Scholar 

  55. Cazaubon S, Parker PJ, Strosberg AD, Couraud P-O (1993) Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein-kinase in astrocytes. Biochem J 293: 381–386

    PubMed  CAS  Google Scholar 

  56. Wang Y, Simonson MS, Pouyssegur J, Dunn MJ (1992) Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells. Biochem J 281: 589–594

    Google Scholar 

  57. Kasuya Y, Abe Y, Hama H et al (1994) Endothelin-1 activates mitogen-activated protein kinases through two independent signaling pathways in rat astrocytes. Biochem Biophys Res Com 204: 1325–1333

    Article  PubMed  CAS  Google Scholar 

  58. Daub H, Weiss FU, Wallasch C, Ullrich A (1996) Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature 379: 557–560

    Article  PubMed  CAS  Google Scholar 

  59. Aquilla E, Whelchel A, Knott HJ, Nelson M, Posada J (1996) Activation of multiple mitogen-activated protein kinase signal transduction pathways by the endothelin B receptor requires the cytoplasmic tail. J Biol Chem 271: 31572–31579

    Article  PubMed  CAS  Google Scholar 

  60. Goto K, Hama H, Kasuya Y (1996) Molecular pharmacology and pathophysiological significance of endothelin. Jpn J Pharmacol 72: 261–290

    Article  PubMed  CAS  Google Scholar 

  61. Stewart AG, Grigoriadis G, Harris T (1994) Mitogenic actions of endothelin-1 and epidermal growth factor in cultured airway smooth muscle. Clin Exp Pharmacol Physiol 21: 277–285

    Article  PubMed  CAS  Google Scholar 

  62. Simonson MS, Wang Y, Herman WH (1996) Nuclear signaling by endothelin-1 requires Src protein-tyrosine kinases. J Biol Chem 271: 11–82

    Google Scholar 

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© 1999 Birkhäuser Verlag

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Krymskaya, V.P., Panettieri, R.A. (1999). Endothelin in Lung Development and Tissue Growth. In: Goldie, R.G., Hay, D.W.P. (eds) Pulmonary Actions of the Endothelins. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8821-9_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8821-9_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-5859-4

  • Online ISBN: 978-3-0348-8821-9

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