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In Vitro Effects of the Endothelins on Airway and Vascular Smooth Muscle Tone

  • Chapter
Pulmonary Actions of the Endothelins

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Endothelin-1 (ET-1) was first isolated from vascular endothelial cells, and susbsequently found in large amount in the lungs, where it is produced mainly by airway epithelial cells and airway macrophages. It is noteworthy that isolated airways and pulmonary vascular preparations, largely because of the abundance of ET receptors in these tissues and the ability to conduct organ bath preparations, have been used extensively in studies investigating ET receptor characterization, subtyping and the different intracellular pathways following activation of these receptors. This field of investigation has rapidly expanded over the last 5 years and it became clear that ET-1 had a large array of functional effects including contraction and relaxation due to direct activation of endothelin receptors, as well as release of mediators and subsequent activation of their corresponding receptors.

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Authors and Affiliations

  1. Inflammatory Diseases Unit, Roche Bioscience, 3401 Hillview Avenue, Palo Alto, CA, 94304-1397, USA

    Claude Bertrand

  2. Faculté de Médecine Paris-Ouest, Laboratoire de Pharmacologie, 15, rue de l’Ecole de Médecine, F-75270, Paris Cedex 06, France

    Emmanuel Naline & Charles Advenier

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  1. Claude Bertrand
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  2. Emmanuel Naline
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Editors and Affiliations

  1. Faculty of Medicine & Dentistry Department of Pharmacology, University of Western Australia, Perth Nedlands, WA, 6907, Australia

    Roy G. Goldie

  2. Department of Pulmonary Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, 19406-0939, USA

    Douglas W. P. Hay

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Bertrand, C., Naline, E., Advenier, C. (1999). In Vitro Effects of the Endothelins on Airway and Vascular Smooth Muscle Tone. In: Goldie, R.G., Hay, D.W.P. (eds) Pulmonary Actions of the Endothelins. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8821-9_6

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  • DOI: https://doi.org/10.1007/978-3-0348-8821-9_6

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-5859-4

  • Online ISBN: 978-3-0348-8821-9

  • eBook Packages: Springer Book Archive

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