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Activity and Distribution of the Endothelin-Converting Enzyme in the Lung

  • Chapter
Pulmonary Actions of the Endothelins

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

Within the intricate capillary and bronchial network of the lungs are found important cellular sources for eicosanoids, cytokines, surfactant and the potent endothelium derived-vasoconstrictor, endothelin-1 [1–3]. In large mammals, the lungs contain only 12% of total blood volume at any given time yet the cross-sectional area of the pulmonary circulation represents 40% of that of the entire vasculature [4]. This would suggest that the pulmonary vascular endothelium has the potential capacity of producing and concentrating in the lungs a significant portion of the total vascular-derived endothelin.

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Authors and Affiliations

  1. Department of Pharmacology, Medical School, Université de Sherbrooke, Sherbrooke, Québec, J1H 5N4, Canada

    Pedro D’Orléans-Juste & Jean-Philippe Gratton

  2. Department of Anatomy and Cell Biology, Medical School, Université de Sherbrooke, Sherbrooke, Québec, J1H 5N4, Canada

    Ghassan Bkaily

  3. Department of Pathology, Montréal General Hospital, 1650 Cedar Avenue, Montréal, Québec, H3G 1A4, Canada

    Adel Giaid

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  1. Pedro D’Orléans-Juste
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  2. Jean-Philippe Gratton
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  3. Ghassan Bkaily
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  4. Adel Giaid
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Editors and Affiliations

  1. Faculty of Medicine & Dentistry Department of Pharmacology, University of Western Australia, Perth Nedlands, WA, 6907, Australia

    Roy G. Goldie

  2. Department of Pulmonary Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, 19406-0939, USA

    Douglas W. P. Hay

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D’Orléans-Juste, P., Gratton, JP., Bkaily, G., Giaid, A. (1999). Activity and Distribution of the Endothelin-Converting Enzyme in the Lung. In: Goldie, R.G., Hay, D.W.P. (eds) Pulmonary Actions of the Endothelins. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8821-9_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8821-9_4

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-5859-4

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