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Cellular Localization of the Endothelin System in the Lung

  • Chapter
Pulmonary Actions of the Endothelins

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Although the endothelium is considered the main site of production of the endothelins, many other cell types in the lung are capable of endothelin synthesis, implying numerous potential roles for endothelins in lung biology. The endothelins were characterised originally as powerful vasoconstrictors, however, it is becoming clear that their effects may vary depending on the predominant receptor subtype present and the initial tone of the vascular bed. In addition, endothelins may be mitogenic and chemotactic for lung fibroblasts and smooth muscle cells derived from the airways or pulmonary circulation. Furthermore, their presence during development raises the possibility that these peptides may contribute to growth of the normal lung in addition to pathological remodelling of the airways and lung vasculature.

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References

  1. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci USA 86: 2863–2867

    Article  PubMed  CAS  Google Scholar 

  2. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411–415

    Article  PubMed  CAS  Google Scholar 

  3. Barnes K, Murphy LJ, Takahashi M, Tanzawa K, Turner AJ (1995) Localization and biochemical characterisation of endothelin-converting enzyme. J Cardiovasc Pharmacol 26(Suppl 3): S37–S39

    PubMed  CAS  Google Scholar 

  4. Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D (1994) ECE-1: a membrane bound metalloproteinase that catalyses the proteolytic activation of big endothelin-1. Cell 78: 473–485

    Article  PubMed  CAS  Google Scholar 

  5. Emoto N, Yanagisawa M (1995) Endothelin converting enzyme-2 is a membrane-bound phosphoramidon-sensitive metalloproteinase with acidic pH optimum. J Biol Chem 270: 15262–15268

    Article  PubMed  CAS  Google Scholar 

  6. Saleh D, Furukawa K, Tsao MS, Maghazachi A, Corrin B, Yanagisawa M, Barnes PJ, Giaid A (1997) Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines. Am J Respir Cell Mol Biol 16: 187–193

    PubMed  CAS  Google Scholar 

  7. Ziegler JW, Ivy DD, Kinsella JP, Abman SH (1995) The role of nitric oxide, endothelin, and prostaglandins in the transition of the pulmonary circulation. Clin Perinatol 22: 387–403

    PubMed  CAS  Google Scholar 

  8. Shyamala V, Moulthrop THM, Stratton-Thomas J, Tekamp-Olson P (1994) Two distinct human endothelin B receptors generated by alternative splicing from a single gene. Cell Mol Biol Res 40: 285–296

    PubMed  CAS  Google Scholar 

  9. Elshourbagy NA, Adamou JE, Gagnon AW, Wu HL, Pullen M, Nambi P (1996) Molecular characterization of a novel human endothelin receptor splice variant. J Biol Chem 271: 25300–25307

    Article  PubMed  CAS  Google Scholar 

  10. MacCumber MW, Ross CA, Glaser BM, Snyder SH (1989) Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action. Proc Natl Acad Sci USA 86: 7285–7289

    Article  PubMed  CAS  Google Scholar 

  11. Giaid A, Polak JM, Gaitonde V, Hamid QA, Moscoso G, Legon S, Uwanogho D, Roncalli M, Shinmi O, Sawamura T (1991) Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung. Am J Respir Cell Mol Biol 4: 50–58

    PubMed  CAS  Google Scholar 

  12. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T, Cao WH, Kamada N (1994) Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 368: 703–710

    Article  PubMed  CAS  Google Scholar 

  13. Kurihara Y, Kurihara H, Oda H, Maemura K, Nagai R, Ishikawa T, Yazaki Y (1995) Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 96: 293–300

    Article  PubMed  CAS  Google Scholar 

  14. Vittori E, Marini M, Fasoli A, De Franchis R, Mattoli S (1992) Increased expression of endothelin in bronchial epithelial cells of asthmatic patients and effects of corticosteroids. Am Rev Respir Dis 146: 1320–1325

    PubMed  CAS  Google Scholar 

  15. Shokeir MO, Pare P, Wright JL (1994) Relation of smoking to immunoreactive endothelin in the bronchiolar epithelial cells. Thorax 49: 786–788

    Article  PubMed  CAS  Google Scholar 

  16. Visner GA, Staples ED, Chesrown SE, Block ER, Zander DS, Nick HS (1994) Isolation and maintenance of human pulmonary artery endothelial cells in culture isolated from transplant donors. Am J Physiol 267: L406–L413

    PubMed  CAS  Google Scholar 

  17. Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD (1990) Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 172: 1741–1748

    Article  PubMed  CAS  Google Scholar 

  18. Ergul A, Glassberg MK, Wanner A, Puett D (1995) Characterization of endothelin receptor subtypes on airway smooth muscle cells. Exp Lung Res 21: 453–468

    Article  PubMed  CAS  Google Scholar 

  19. Rozengurt N, Springall DR, Polak JM (1990) Localization of endothelin-like immunoreactivity in airway epithelium of rats and mice. J Patkol 160: 5–8

    Article  CAS  Google Scholar 

  20. Yoshimi H, Hirata Y, Fukuda Y, Kawano Y, Emori T, Kuramochi M (1989) Regional distribution of immunoreactive endothelin in rats. Peptides 10: 805–808

    Article  PubMed  CAS  Google Scholar 

  21. Hemsen A, Franco-Cereceda A, Matran R, Rudehill A, Lundberg JM (1990) Occurrence, specific binding sites and functional effects of endothelin in human cardiopulmonary tissue. Eur J Pharmacol 191: 319–328

    Article  PubMed  CAS  Google Scholar 

  22. Marciniak SJ, Plumpton C, Barker PJ, Huskisson NS, Davenport AP (1992) Localization of immunoreactive endothelin and proendothelin in the human lung. Pulm Pharmacol 5: 175–182

    Article  PubMed  CAS  Google Scholar 

  23. Mattoli S, Soloperto M, Marini M, Fasoli A (1991) Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J Allergy Clin Immunol 88: 376–384

    Article  PubMed  CAS  Google Scholar 

  24. Springall DR, Howarth PH, Counihan H, Djukanovic R, Holgate ST, Polak JM (1991) Endothelin immunoreactivity of airway epithelium in asthmatic patients. Lancet 337: 697–701

    Article  PubMed  CAS  Google Scholar 

  25. Ackerman V, Carpi S, Bellini A, Vassali G, Marini M, Mattoli S (1995) Constitutive expression of endothelin in bronchial epithelial cells of patients with symptomatic and asymptomatic asthma and modification by histamine and interleukin-1. J Allergy Clin Immunol 96: 618–627

    Article  PubMed  CAS  Google Scholar 

  26. Carpi S, Marini M, Vittori E, Vassli G, Mattoli S (1993) Bronchoconstrictive responses to inhaled ultrasonically nebulised distilled water and airway inflammation in asthma. Chest 104: 1346–1351

    Article  PubMed  CAS  Google Scholar 

  27. Advenier C, Sarria B, Naline E, Puybasset L, Lagente V (1990) Contractile activity of three endothelins (ET-1, ET-2, ET-3) on the human isolated bronchus. Br J Pharmacol 100: 168–172

    PubMed  CAS  Google Scholar 

  28. Hay DWP, Luttman MA, Hubbard WC, Undem BJ (1993) Endothelin receptor subtypes in human and guinea pig pulmonary tissues. Br J Pharmacol 110: 1175–1183

    PubMed  CAS  Google Scholar 

  29. Goldie RG, Henry PJ, Knott PG, Self GJ, Luttman MA, Hay DWP (1995) Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways. Am J Respir Crit Care Med 152: 1653–1658

    PubMed  CAS  Google Scholar 

  30. Goldie RG, Grayson PS, Knott PG, Self GJ, Henry PJ (1994) Predominance of endothelin A (ETA) receptors in ovine airway smooth muscle and their mediation of ET-1-induced contraction. Br J Pharmacol 112: 749–756

    PubMed  CAS  Google Scholar 

  31. Goldie RG, Henry PJ, Paterson JW, Preuss JMH, Rigby PJ (1990) Contractile effects and receptor distributions for endothelin-1 (ET-1) in human and animal airways. Agents Actions Suppl 31: 229–232

    Article  CAS  Google Scholar 

  32. Power RF, Wharton J, Zhao Y, Bloom SR, Polak JM (1989) Autoradiographic localization of endothelin-1 binding sites in the cardiovascular and respiratory systems. J Cardiovasc Pharmacol 13 (Suppl 5): S50–S56

    Article  PubMed  CAS  Google Scholar 

  33. McKay KO, Black JL, Diment LM, Armour CL (1991) Functional and autoradiographic studies of endothelin-1 and endothelin-2 in human bronchi, pulmonary arteries, and airway parasympathetic ganglia. J Cardiovasc Pharmacol 17 (Suppl 7): S206–S209

    Article  PubMed  CAS  Google Scholar 

  34. Wu T, Mullol J, Rieves RD, Logun C, Hausfield J, Kaliner MA, Shelhamer JH (1992) Endothelin-1 stimulates eicosanoid production in cultured human nasal mucosa. Am J Respir Cell Mol Biol 6: 168–174

    PubMed  CAS  Google Scholar 

  35. Glassberg MK, Ergul A, Wanner A, Puett D (1994) Endothelin-1 promotes mitogenesis in airway smooth muscle cells. Am J Respir Cell Mol Biol 10: 316–321

    PubMed  CAS  Google Scholar 

  36. Panettieri RA Jr, Goldie RG, Rigby PJ, Eszterhas AJ, Hay DW (1996) Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon. Br J Pharmacol 118: 191–197

    PubMed  CAS  Google Scholar 

  37. Brewster CEP, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR (1990) Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 3: 507–511

    PubMed  CAS  Google Scholar 

  38. Henry PJ, Goldie RG (1994) ETB but not ETA receptor-mediated contractions to endothelin-1 attenuated by respiratory tract viral infection in mouse airways. Br J Pharmacol 112: 1188–1194

    PubMed  CAS  Google Scholar 

  39. Giaid A, Michel RP, Stewart DJ, Sheppard M, Corrin B, Hamid Q (1993) Expression of endothelin-1 in lungs of patients with fibrosing cryptogenic alveolitis. Lancet 341: 1550–1554

    Article  PubMed  CAS  Google Scholar 

  40. Kuwahara M, Kuwahara M, Suzuki N (1992) Production of endothelin-1 and big-endothelin-1 by pleural mesothelial cells. FIBS Lett 298: 21–24

    Article  CAS  Google Scholar 

  41. Seldeslagh KA, Lauweryns JM (1993) Endothelin in normal lung tissue of newborn mammals: immunocytochemical distribution and co-localization with serotonin and calcitoningene related peptide. J Histochem Cytochem 41: 1495–1502

    Article  PubMed  CAS  Google Scholar 

  42. Sofia M, Mormile M, Faraone S, Alifano M, Zofra S, Romano L, Carratu L (1993) Increased endothelin-like immunoreactive material in bronchoalveolar lavage fluid from patients with bronchial asthma and patients with interstitial lung disease. Respiration 60: 89–95

    Article  PubMed  CAS  Google Scholar 

  43. Uguccioni M, Pulsatelli L, Grigolo B, Facchini A, Fasano L, Cinti C, Fabbri M, Gasbarrini G, Meliconi R (1995) Endothelin-1 in idiopathic pulmonary fibrosis. J Clin Pathol 48: 330–334

    Article  PubMed  CAS  Google Scholar 

  44. MacNulty EE, Plevin R, Wakelam MJ (1990) Stimulation of the hydrolysis of phosphat-idylinositol 4,5-biphosphate and phosphatidylcholine by endothelin, a complete mitogen for rat fibroblasts. Biochem J 272: 761–766

    PubMed  CAS  Google Scholar 

  45. Peacock AJ, Dawes KE, Shock A, Gray AJ, Reeves JT, Laurent GJ (1992) Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts. Am J Respir Cell Mol Biol 7: 492–499

    PubMed  CAS  Google Scholar 

  46. Marini M, Carpi C, Bellini A, Patalano F, Mattoli S (1996) Endothelin-1 induces increased fibronectin expression in human bronchial epithelial cells. Biochem Biophys Res Commun 220: 896–899

    Article  PubMed  CAS  Google Scholar 

  47. Guarda E, Katwa LC, Myers PR, Tyagi SC, Weber KT (1993) Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc Res 27: 2130–2134

    Article  PubMed  CAS  Google Scholar 

  48. Calderon E, Gomez-Sanchez CE, Cozza EN, Zhou M, Coffey RG, Lockey RF, Prockop LD, Szentivanyi A (1994) Modulation of endothelin-1 production by a pulmonary epithelial cell line, I: regulation by glucocorticoids. Biochem Pharmacol 48: 2065–2071

    Article  PubMed  CAS  Google Scholar 

  49. Markewitz BA, Kohan DE, Michael JR (1995) Endothelin-1 synthesis, receptors and signal transduction in a cloned rat epithelial cell line: evidence for an autocrine role. Am J Physiol 268: L192–L200

    PubMed  CAS  Google Scholar 

  50. Knott PG, D’Aprile AC, Henry PJ, Hay DWP, Goldie RG (1995) Receptors for endothelin-1 in asthmatic human peripheral lung. Br J Pharmacol 114: 1–3

    PubMed  CAS  Google Scholar 

  51. Cambrey AD, Harrison NK, Dawes KE, Southcott AM, Black CM, du Bois RM, Laurent GJ, McAnulty RJ (1994) Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro. Am J respir Cell Mol Biol 11: 439–445

    PubMed  CAS  Google Scholar 

  52. Durham SK, Goller NL, Lynch JS, Fisher SM, Rose PM (1993) Endothelin receptor B expression in the rat and rabbit lung as determined by in situ hybridization using nonisotopic probes. J Cardiovasc Pharmacol 22 (Suppl 8): S1–S3

    Article  PubMed  CAS  Google Scholar 

  53. Sen N, Grunstein MM, Chander A (1994) Stimulation of lung surfactant secretion by endothelin-1 from rat alveolar type II cells. Am J Physiol 266: L255–L262

    PubMed  CAS  Google Scholar 

  54. Markewitz BA, Michael JR, Kohan DE (1997) Endothelin-1 inhibits the expression of inducible nitric oxide synthase. Am J Physiol 272: L1078–L1083

    PubMed  CAS  Google Scholar 

  55. Giaid A, Hamid QA, Springall DR, Yanagisawa M, Shinmi O, Sawamura T, Masaki T, Kimura S, Corrin B, Polak JM (1990) Detection of endothelin immunoreactivity and mRNA in pulmonary tumours. J Pathol 162: 15–22

    Article  PubMed  CAS  Google Scholar 

  56. Shichiri M, Hirata Y, Nakajima T, Ando K, Imai T, Yanagisawa M, Masaki T, Marumo F (1991) Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines. J Clin Invest 87: 1867–1871

    Article  PubMed  CAS  Google Scholar 

  57. Wagner OF, Christ G, Wojta J, Vierhapper H, Parzer S, Nowotny PJ, Schneider B, Waldhäusl W, Binder BR (1992) Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 267: 16066–16068

    PubMed  CAS  Google Scholar 

  58. Takahashi M, Fukuda K, Shimada K, Barnes K, Turner AJ, Ikeda M, Koike H, Yamamoto Y, Tanzawa K (1995) Localization of rat endothelin converting enzyme to vascular endothelial cells and some secretory cells. Biochem J 311: 657–665

    PubMed  CAS  Google Scholar 

  59. Ohlstein EH, Arleth A, Ezekiel M, Horohonich S, Ator MA, Caltabiano MM, Sung C-P (1990) Biosynthesis and modulation of endothelin from bovine pulmonary artery endothelial cells. Life Sci 46: 181–188

    Article  PubMed  CAS  Google Scholar 

  60. Golden CL, Kohler JP, Nick HS, Visner GA (1995) Effects of vasoactive and inflammatory mediators on endothelin-1 expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol 12: 503–512

    PubMed  CAS  Google Scholar 

  61. Ryan US, Zhong R, Hayes BA, Visner G, Sauther ML (1993) Regulation of endothelin-1 expression in normal and transfected endothelial cells. J Cardiovasc Pharmacol 22 (Suppl 8): S38–S41

    Article  PubMed  CAS  Google Scholar 

  62. Imai T, Hirata Y, Emori T, Yanagisawa M, Masaki T, Marumo F (1992) Induction of endthelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension 19: 753–757

    PubMed  CAS  Google Scholar 

  63. Prins BA, Hu R-M, Nazario B, Pedram A, Frank HJL, Weber MA, Levin ER (1994) Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells. J Biol Chem 269: 11938–11944

    PubMed  CAS  Google Scholar 

  64. Yoshizumi M, Kurihara H, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Yazaki Y (1989) Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells. Biochem Biophys Res Commun 161: 859–864

    Article  PubMed  CAS  Google Scholar 

  65. Yu JCM, Davenport AP (1995) Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells. Br J Pharmacol 114: 551–557

    PubMed  CAS  Google Scholar 

  66. Zamora MA, Dempsey EC, Walchak SJ, Stelzner TJ (1993) BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 9: 429–433

    PubMed  CAS  Google Scholar 

  67. Li H, Chen SJ, Chen Y-F, Meng QC, Durand J, Oparil S, Elton TS (1994) Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J Appl Physiol 77: 1451–1459

    PubMed  CAS  Google Scholar 

  68. Stelzner TJ, O’Brien RF, Yanagisawa M, Sakurai T, Sato K, Webb S, Zamora M, McMurtry IF, Fisher JH (1992) Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am J Physiol L614-620

    Google Scholar 

  69. Ono S, Westcott JY, Voelkel NF (1992) PAF antagonists inhibit pulmonary vascular remodelling induced by hypobaric hypoxia in rats. J Appl Physiol 73: 1084–1092

    PubMed  CAS  Google Scholar 

  70. Bonvallet ST, Zamora MR, Hasunuma K, Sato K, Hanasato N, Anderson D, Sato K, Stelzner TJ (1994) BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am J Physiol 266: H1327–H331

    PubMed  CAS  Google Scholar 

  71. Giaid A, Stewart DJ, Michel RP (1993) Endothelin-1-like immunoreactivity in postobstructive pulmonary vasculopathy. J Vasc Res 30: 333–338

    Article  PubMed  CAS  Google Scholar 

  72. Kourembanas S, Marsden PA, McQuillan LP, Faller DV (1991) Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest 88: 1054–1057

    Article  PubMed  CAS  Google Scholar 

  73. Hassoun PM, Thappa V, Landman MJ, Fanburg BL (1992) Endothelin-1: mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc Soc Exp Biol Med 199: 165–170

    PubMed  CAS  Google Scholar 

  74. Wiebke JL, Montrose-Rafizadeh C, Zeitlein PL, Guggino WB (1992) Effect of hypoxia on endothelin-1 production by pulmonary vascular endothelial cells. Biochim Biophys Acta 1134: 105–111

    Article  PubMed  CAS  Google Scholar 

  75. Markewitz BA, Kohan DE, Michael JR (1995) Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells. Am J Physiol 269: L215–L220

    PubMed  CAS  Google Scholar 

  76. Cacoub P, Dorent R, Nataf P, Carayon A (1993) Endothelin-1 in pulmonary hypertension. N Engl J Med 329: 1967–1968

    Article  PubMed  CAS  Google Scholar 

  77. Stewart DJ, Levy RD, Cernacek P, Langleben D (1991) Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med 114: 464–469

    PubMed  CAS  Google Scholar 

  78. Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, Shennib H, Kimura S, Masaki T, Duguid WP, Stewart DJ (1993) Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 328: 1732–1739

    Article  PubMed  CAS  Google Scholar 

  79. Zhao YD, Springall DR, Hamid Q, Yacoub MH, Levene M, Polak JM (1995) Localization and characterization of endothelin-1 binding sites in the transplanted human lung. J Cardiovasc Pharmacol 26 Suppl 3: S336–S340

    PubMed  CAS  Google Scholar 

  80. Hagiwara H, Nagasawa T, Yamamoto T, Lodhi KM, Ito T, Takemura N, Hirose S (1993) Immunochemical characterization and localization of endothelin ETB receptor. Am J Physiol 264: R777–R783

    PubMed  CAS  Google Scholar 

  81. Davenport AP, O’Reilly G, Molenaar P, Maguire JJ, Kuc RE, Sharkey A, Bacon CR, Ferro A (1993) Human endothelin receptors characterised using reverse transcriptase-polymerase chain reaction, in situ hybridisation, and subtype selective ligands BQ123 and BQ3020: evidence for expression of ETB receptors in human vascular smooth muscle. J Cardiovasc Pharmacol 22 (Suppl 8): S22–S25

    Article  PubMed  CAS  Google Scholar 

  82. Fukuroda T, Kobayashi M, Ozaki S, Yano M, Miyauchi T, Onizuka M, Sugishita Y, Goto K, Nishikibe M (1994) Endothelin receptor subtypes in human versus rabbit pulmonary arteries. J Appl Physiol 76: 1976–1982

    PubMed  CAS  Google Scholar 

  83. McCulloch KM, Docherty CC, Morecroft I, MacLean MR (1996) Endothelin B receptor-mediated contraction in human pulmonary resistance arteries. Br J Pharmacol 119: 1125–1130

    PubMed  CAS  Google Scholar 

  84. Bialecki RA, Fisher CS, Murdoch WW, Barthlow HG, Bertelsen DL (1997) Functional comparison of endothelin receptors in human and rat pulmonary artery smooth muscle. Am J Physiol 272: L211–L218

    PubMed  CAS  Google Scholar 

  85. Li H, Elton TS, Chen YF, Oparil S (1994) Increased endothelin receptor gene expression in hypoxic rat lung. Am J Physiol 266: L553–L560

    PubMed  CAS  Google Scholar 

  86. Eddahibi S, Springall DR, Mannan M, Carville C, Chabrier P-E, Levanne M, Raffestin B, Polak JM, Adnot S (1993) Dilator effect of endothelins in the pulmonary circulation: changes associated with chronic hypoxia. Am J Physiol 265: L571–L580

    PubMed  CAS  Google Scholar 

  87. Noguchi Y, Hislop AA, Haworth SG (1997) Influence of hypoxia on endothelin-1 binding sites in neonatal porcine pulmonary vasculature. Am J Physiol 272: H669–H678

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Medicine, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK

    Nicholas W. Morrell

  2. Department of Histochemistry, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK

    Carlos Orte, John Wharton & Julia M. Polak

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  1. Nicholas W. Morrell
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  2. Carlos Orte
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  3. John Wharton
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  4. Julia M. Polak
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Editors and Affiliations

  1. Faculty of Medicine & Dentistry Department of Pharmacology, University of Western Australia, Perth Nedlands, WA, 6907, Australia

    Roy G. Goldie

  2. Department of Pulmonary Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, 19406-0939, USA

    Douglas W. P. Hay

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© 1999 Birkhäuser Verlag

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Morrell, N.W., Orte, C., Wharton, J., Polak, J.M. (1999). Cellular Localization of the Endothelin System in the Lung. In: Goldie, R.G., Hay, D.W.P. (eds) Pulmonary Actions of the Endothelins. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8821-9_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8821-9_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-5859-4

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