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Inhibition of the gastric proton pump

  • Chapter
Proton Pump Inhibitors

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

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Abstract

For many years pharmacologists have utilized knowledge of the regulation of gastric acid secretion to discover and develop antisecretory agents. The first agents to emerge were the anticholinergic ones. These were associated with side effects, such as blurred vision, and also with a relatively modest level of efficacy. Success came with the discovery of histamine H2-receptor antagonists, which were found to be both efficacious and selective. The introduction of these agents, in particular cimetidine, revolutionized the treatment of peptic ulcer disorders. Formerly, substantial efforts were also made to discover selective gastrin-receptor antagonists, since gastrin was known to play a central role in stimulating gastric acid secretion. Despite these efforts, no clinically useful agents of this type emerged. Only more recently have nonpeptide, selective CCK-B receptor subtype antagonists been synthesized and tested experimentally.

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Author information

Authors and Affiliations

  1. Astra Hässle AB, Preclinical R&D, S-431 83, Mölndal, Sweden

    Björn Wallmark

  2. UCLA, VA Wadsworth, Los Angeles, CA, 90073, USA

    George Sachs

Authors
  1. Björn Wallmark
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  2. George Sachs
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Editor information

Editors and Affiliations

  1. Centre for Gastroenterological Research, University of Göteborg, S-41345, Göteborg, Sweden

    Lars Olbe

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© 1999 Springer Basel AG

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Wallmark, B., Sachs, G. (1999). Inhibition of the gastric proton pump. In: Olbe, L. (eds) Proton Pump Inhibitors. Milestones in Drug Therapy MDT. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8795-3_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8795-3_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9777-8

  • Online ISBN: 978-3-0348-8795-3

  • eBook Packages: Springer Book Archive

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