Abstract
Twelve children with IBD (5 Crohn’s disease and 7 Ulcerative colitis) were studied with the 99mTc labelled antigranulocyte Mab BW 250/183 (early and late planar scans, early SPET). The SPET study offered higher sensitivity than both early and late planar studies. Endoscopic and scintigraphic results were concordant in 17/25 and 17 /28 segments respectively in the Crohn and ulcerative colitis group of pts. On an individual pt. basis all Crohn pts were true +ve, while in the ulcerative colitis group 3 were true+ve, 1 false-ve and 1 false +ve.
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Kipper SL. Radiolabeled leukocyte imaging of the abdomen. In: Nuclear Medicine Annual 1995. Freeman LM, ed. New York: Raven Press, 1995:81–128.
Charron M, Orenstein SR, Bhargava S. Detection of inflammatory bowel disease in pediatric patients with technetium-99m-HMPAO-labeled leukocytes. J Nucl Med 1994;35:451–455
Shah DB, Cosgrove M, Rees JI, Jenkins HR. The technetium white cell scan as an initial imaging investigation for evaluating suspected childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 1997;25:524–528.
Joseph K, Hoffken H, Bosslet K, Schorlemmer HU. In vivo labelling of granulocytes with 99mTc anti-NCA monoclonal antibodies for imaging inflammation. Eur J Nucl Med 1988;14:367–373.
Mahida YR, Perkins AC, Frier M, Wasie ML, Hawkey CJ. Monoclonal antigranulocyte antibody imaging in inflammatory bowel disease:a preliminary report. Nucl Med Commun 1992;13:330–335.
Steinstrasser A, Oberhausen E. Granulocyte labelling kit BW 250/183. Results of the European Multicenter Trial. Nucl-Med 1996;35:1–11
Segarra I, Roca M, Baliellas C et al. Granulocyte-specific monoclonal antibody technetium99m-BW 250/183 and indium-1ll oxine-labelled leucocyte scintigraphy in inflammatory bowel disease. Eur J Nucl Med 1991;18:715–719
Almers S, Granerus G, Franzen L, Strom M. technetium-99m scintigraphy: more accurate assesment of ulcerative colitis with exametazime-labelled leucocytes than with antigranulocyte antibodies. Eur J Nucl Med 1996;23:247–255
Hyams JS, Ferry GD, Mandel FS et al. Development and validation of a pediatric Crohn’s disease activity index. J Pediatr Gastroenterol Nutr 1991;12:439–447
Rachmilewitz D. Coated mesalazine (5-aminosalycilic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomized trial. B M J 1989:298:82–86.
Becker WS, Saptogino A, Wolf FG. The single late 99mTc granulocyte antibody scan in inflammatory diseases:a preliminary report. Nucl Med Commun 1992;13:186–192.
Kroiss A, Weiss W, Auinger C et al. Immunoscintigraphy (IS) with I-123 and Tc-99m labeled granulocytes antibody (Ab) in patient with inflammatory bowel diseases. Prog Clin Biol Res 1990;31:319–325
Aprile C, Saponaro R, Cannizzaro G. Leserbriefe. Nucl-Med 1996;35: (65)
Almer S, Franzen L, Peters AM et al. Do technetium-99m hexamethylpropylene amino oxime-labeled leukocytes truly reflect the mucosal inflammation in patients with ulcerative colitis?. Scand J Gastroenterol 1992;27:1031–1038.
Ivancevic V, Munz DL. Non specific bowel activity in 99mTc-labelled monoclonal antigranulocyte antibody imaging. Nuc Med Commun 1992; 13:899–900
Ivancevic V, Schworer H, Sandrock D et al. Falsely negative 99mTc-Antigranulocyte immunoscintigraphy and positive 99mTc-HMPAO-labelled leukocyte scan in active Crohn’s disease. Nucl-Med 1995;34:248–251.
Papos M, Nagy F, Narai Gy et al. Immunoscintigraphy (IS) with antigranulocyte monoclonal antibody and HMPAO-labeled white blood cell scintigraphy (WBS) in inflammatory bowel disease (IBD). Eur J Nucl Med 1993;20:938 (abst).
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Aprile, C., De Giacomo, C., Valdambrini, V., Cannizzaro, G., Saponaro, R. (1999). Detection of Inflammatory Bowel Diseases in Children with 99m Tc Antigranulocyte Mab (BW 250/183) Scintigraphy. In: Bergmann, H., Köhn, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research XXIII. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8782-3_42
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DOI: https://doi.org/10.1007/978-3-0348-8782-3_42
Publisher Name: Birkhäuser, Basel
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