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Role of eicosanoids in psoriasis and atopic skin diseases

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Fatty Acids and Inflammatory Skin Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

As described in detail in the chapter on arachidonic acid metabolism in the skin, eicosanoids are formed after oxygenation of arachidonic acid. Prostaglandins are formed by the cyclooxygenese (CO) pathway, whereas leukotrienes (LTs) and hydroxyeicosatetraenoic acids (HETEs) are formed by the 5-, 12- and 15-lipoxyge-nase (LO) pathways. 5- and 12-LO products are mainly proinflammatory in the skin, whereas the main 15-LO product 15-HETE has antiinflammatory capacities.

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  1. Department of Dermatology, Marselisborg Hospital, University of Aarhus, DK-8000, Aarhus C, Denmark

    Karsten Fogh & Knud Kragballe

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  1. Karsten Fogh
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  1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105, Kiel, Germany

    Jens-Michael Schröder

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Fogh, K., Kragballe, K. (1999). Role of eicosanoids in psoriasis and atopic skin diseases. In: Schröder, JM. (eds) Fatty Acids and Inflammatory Skin Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8761-8_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8761-8_3

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