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Possibilities and problems of cytokine measurements

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Cytokines in Severe Sepsis and Septic Shock

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The appearance of detectable pro- as well as anti-inflammatory cytokines in the blood-stream during sepsis is indicative of their exacerbated production. The interaction of micro-organisms and their derived products with host cells rapidly leads to the production of many inflammatory mediators including cytokines. Two major features characterize the production of these factors: cascade and regulatory loops. This means that, once produced, a given cytokine can induce the production of others which can further induce cytokine release or, on the contrary, down-regulate the upstream synthesis. Usually absent from the plasma at homeostasis, many cytokines are produced in such large amounts during sepsis that they can be detected in the circulation of the patients. Due to limitation of space, this review will attempt to focus on human sepsis, while mentioning animal models when necessary.

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  1. Unité d’Immuno-Allergie, Institut Pasteur, 28 rue du Dr. Roux, F-75015, Paris, France

    Jean-Marc Cavaillon

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  1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A-1200, Vienna, Austria

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Cavaillon, JM. (1999). Possibilities and problems of cytokine measurements. In: Redl, H., Schlag, G. (eds) Cytokines in Severe Sepsis and Septic Shock. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8755-7_6

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  • DOI: https://doi.org/10.1007/978-3-0348-8755-7_6

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