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Nerve growth factor and sensory nerve function

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Pain and Neurogenic Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Nerve growth factor (NGF) was the first described neurotrophic factor and it remains the best studied. This molecule regulates the growth, survival and phenotypic properties of restricted subsets of neurones and these properties have received much experimental examination. There is also currently considerable interest in the potential therapeutic uses of this molecule in two broad areas. The first derives from the hope that NGF in particular and neurotrophic factors in general will prove useful in the treatment of neurodegenerative disorders (see [1] for review). The hope is that since these molecules exert profound survival-promoting effects in the developing animal, they may also be of benefit in arresting or reversing degenerative or atrophic changes associated with disease states. Data from the study of animal models of degenerative diseases are encouraging. Very recently, a phase III clinical trial has started using NGF for the treatment of human diabetic neuropathy or HIV. The results of preceding trials have been published.

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Authors and Affiliations

  1. Division of Physiology, U.M.D.S, London, UK

    David L. H. Bennett & Stephen B. McMahon

  2. Division of Biochemistry and Molecular Biology, U.M.D.S, London, UK

    Marcus Rattray

  3. Department of Neuroscience, Genentech Inc., South San Francisco, USA

    David L. Shelton

Authors
  1. David L. H. Bennett
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  2. Stephen B. McMahon
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  3. Marcus Rattray
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  4. David L. Shelton
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  1. Cardiovascular Research Centre, Division of Biomedical Sciences, King’s College London, Manresa Road, SW3 6LX, London, UK

    Susan D. Brain

  2. Messengers and Signalling Group, Division of Biomedical Sciences, King’s College London, Manresa Road, SW3 6LX, London, UK

    Philip K. Moore

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Bennett, D.L.H., McMahon, S.B., Rattray, M., Shelton, D.L. (1999). Nerve growth factor and sensory nerve function. In: Brain, S.D., Moore, P.K. (eds) Pain and Neurogenic Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8753-3_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8753-3_9

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