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Sensory neuropeptides, neurogenic inflammation and inflammatory cells

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Pain and Neurogenic Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The term neurogenic inflammation was first used to describe the contribution of sensory nerves to local inflammatory responses [1]. There is a large body of research dating back to the last century that documents the role of sensory nerves in vascular aspects of inflammatory responses. The sensory neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP) are potent vasoactive peptides found in nociceptive nerve endings. Following a noxious stimulus they are released at local sites where they coordinate the activities of different cells and tissues involved in inflammatory and immune responses. In addition to their vascular effects SP and CGRP also regulate the function of leukocytes involved in immune and inflammatory responses. (The term leukocyte refers collectively to all white blood cells. This includes lymphocytes, monocytes, macrophages and granulocytes.)

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  1. Department of Microbiology and Immunology, University of Kentucky, College of Medicine, Lexington, 40536-0084, KY, USA

    Joseph P. McGillis & Stefan Fernandez

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  1. Cardiovascular Research Centre, Division of Biomedical Sciences, King’s College London, Manresa Road, SW3 6LX, London, UK

    Susan D. Brain

  2. Messengers and Signalling Group, Division of Biomedical Sciences, King’s College London, Manresa Road, SW3 6LX, London, UK

    Philip K. Moore

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McGillis, J.P., Fernandez, S. (1999). Sensory neuropeptides, neurogenic inflammation and inflammatory cells. In: Brain, S.D., Moore, P.K. (eds) Pain and Neurogenic Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8753-3_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8753-3_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9758-7

  • Online ISBN: 978-3-0348-8753-3

  • eBook Packages: Springer Book Archive

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