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Mast Cell Proteases as New Targets for Therapeutic Intervention in Asthma

  • Chapter
Anti-Inflammatory Drugs in Asthma

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Mast cells have long attracted attention for their potential to contribute to the disease process in asthma [1]. These cells are widely distributed throughout the body, but are particularly prevalent in tissues which form an interface with the external environment. In the lower airways mast cells are numerous in the bronchial mucosa [2], submucosa and alveolar walls [3], and are even found free in the lumen [4]. The activation of mast cells by allergen or by other stimuli is associated with the rapid release of a range of potent mediators of inflammation and bronchoconstriction.

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  1. Immunopharmacology Group, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK

    Steven J. Compton & Andrew F. Walls

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  1. Steven J. Compton
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  2. Andrew F. Walls
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  1. Immunopharmacology Group, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK

    Anthony P. Sampson  & Martin K. Church  & 

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Compton, S.J., Walls, A.F. (1999). Mast Cell Proteases as New Targets for Therapeutic Intervention in Asthma. In: Sampson, A.P., Church, M.K. (eds) Anti-Inflammatory Drugs in Asthma. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8751-9_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8751-9_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9757-0

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