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Anti-Leukotriene Therapy for Asthma

  • Chapter
Anti-Inflammatory Drugs in Asthma

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Human bronchial asthma is a chronic disorder of the airways, associated in most cases with atopy (i.e. specific immunoglobulin E responses to allergens), and characterised by a range of abnormalities on various levels. Early definitions of asthma stressed the aspects of variable lung function, reversible spontaneously or with treatment, but more recent definitions also place emphasis on the underlying airway inflammation that is thought to promote bronchial hyperresponsiveness [1]. The asthma syndrome comprises firstly, clinical symptoms, such as chest tightness, dyspnoea, coughing, and/or wheeze, secondly, pathophysiological features, such as variable airway obstruction and bronchial hyperresponsiveness (BHR) to a variety of stimuli which may be physical (e.g. cold dry air, hyper/hypotonic saline), pharmacological (e.g. histamine, methacholine), chemical (e.g. SO2), or physiological (e.g. exercise), and thirdly, pathohistological parameters, particularly eosinophilic airway inflammation, resulting in structural changes within the airways (“airway remodelling”) [2, 3]. Asthma may occur in varying degrees of severity ranging from intermittent to severe persistent forms [1].

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  1. Department of Respiratory Diseases, Erasmus University Medical Centre Rotterdam, Dr Molewaterplein 40, NL-3015 GD, Rotterdam, The Netherlands

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  2. Immunopharmacology Group, Level F, Centre Block (825), Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK

    Anthony P. Sampson

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Diamant, Z., Sampson, A.P. (1999). Anti-Leukotriene Therapy for Asthma. In: Sampson, A.P., Church, M.K. (eds) Anti-Inflammatory Drugs in Asthma. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8751-9_6

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