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Anti-Inflammatory Drugs in Asthma: The Pathophysiology of Asthma

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Anti-Inflammatory Drugs in Asthma

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Asthma is a chronic condition characterised by widespread, variable and reversible airflow obstruction which is either spontaneous or pharmacologically induced. The underlying pathophysiological feature of asthma is increased airway responsiveness which develops on a basis of diffuse bronchial inflammation. The prevalence of asthma is increasing worldwide despite improved treatment which has resulted from a more comprehensive understanding of its pathogenesis [1]. In most countries asthma affects between 4 and 8% of the population, with a trend towards an increase in morbidity as judged by increased hospital admissions [2]. The reasons for this are unclear, but environmental factors such as indoor and outdoor air pollution and changes in lifestyle are considered to be amongst the contributing factors.

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Lordan, J.L., Djukanović, R. (1999). Anti-Inflammatory Drugs in Asthma: The Pathophysiology of Asthma. In: Sampson, A.P., Church, M.K. (eds) Anti-Inflammatory Drugs in Asthma. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8751-9_1

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