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Overview of inflammatory cytokines and their role in pain

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Cytokines and Pain

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cytokines are small, non-structural proteins with molecular weights ranging from 8–40,000 Daltons. Originally called lymphokines and monokines to indicate their cellular sources, it became clear that the term “cytokine” is the best description since nearly all nucleated cells are capable of synthesising of these proteins and, in turn, respond to them. There is no amino acid sequence motif or three dimensional structure that links cytokines; rather, their biological activities allow us to group them into different classes. For the most part, cytokines are primarily involved in host responses to disease or infection and any involvement with homeostatic mechanisms has been less than dramatic. At least that is the present wisdom derived from gene deletion studies in mice.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO, 80262, USA

    Charles A. Dinarello

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  1. Charles A. Dinarello
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Editors and Affiliations

  1. Dept. of Psychology, University of Colorado at Boulder, Boulder, CO, 80309-0345, USA

    Linda R. Watkins  & Steven F. Maier  & 

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© 1999 Springer Basel AG

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Dinarello, C.A. (1999). Overview of inflammatory cytokines and their role in pain. In: Watkins, L.R., Maier, S.F. (eds) Cytokines and Pain. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8749-6_1

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  • DOI: https://doi.org/10.1007/978-3-0348-8749-6_1

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9756-3

  • Online ISBN: 978-3-0348-8749-6

  • eBook Packages: Springer Book Archive

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