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The role of PECAM in leukocyte emigration

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Vascular Adhesion Molecules and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The process of leukocyte emigration into a site of inflammation involves a number of sequential and coordinated adhesive interactions between the leukocyte and underlying endothelium. As has been made clear in previous chapters, emigration can be dissected into the steps of tethering, rolling, activation, firm adhesion, and transendothelial migration. These interactions typically involve distinct families of cell adhesion molecules (CAMs). It is our ability to block the actions of these molecules by specific monoclonal antibodies (mAb), soluble recombinant CAMs or their ligands, or genetic disruption that has identified these as distinct steps [1,2].

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Authors and Affiliations

  1. Department of Pathology and the Center for Vascular Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, 10021, USA

    William A. Muller

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  1. William A. Muller
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Editors and Affiliations

  1. Centre for Cardiovascular Biology and Medicine, School of Biomedical Sciences King’s College London, Guy’s Campus, London, SE1 9RT, UK

    Jeremy D. Pearson

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© 1999 Springer Basel AG

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Muller, W.A. (1999). The role of PECAM in leukocyte emigration. In: Pearson, J.D. (eds) Vascular Adhesion Molecules and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8743-4_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8743-4_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9753-2

  • Online ISBN: 978-3-0348-8743-4

  • eBook Packages: Springer Book Archive

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