Skip to main content
SpringerLink
Log in
Book cover

Apoptosis and Inflammation pp 101–119Cite as

Birkhäuser

Chondrocyte apoptosis

  • Chapter

  • 100 Accesses

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Articular cartilage is the site of pathologic matrix remodeling and degradation in arthritis [1]. Principally two forms of arthritis can be distinguished. The inflammatory arthropathies, such as rheumatoid arthritis (RA) are the result of an aberrant immune and inflammatory response in the synovium which leads to the degradation of the articular cartilage. This is in contrast to the pathogenesis of osteoarthritis (OA), the most common joint disease, where a time or age dependent process leads to aberrant cartilage matrix remodeling which is characterized by loss of existing cartilage extracellular matrix, the production of matrix with abnormal composition and pathologic matrix calcification.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Poole AR (1997) Cartilage in health and disease. In: WJ Koopman (ed): Arthritis and allied conditions. Williams and Wilkins, Baltimore, 255–308

    Google Scholar 

  2. Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM (1997) Principles of cartilage repair and regeneration. Clin Orthop 342: 254–269

    Article  PubMed  Google Scholar 

  3. Ishizaki Y, Burne JF, Raff MC (1994) Autocrine signals enable chondrocytes to survive in culture. J Cell Biol 126: 1069–1077

    Article  PubMed  CAS  Google Scholar 

  4. Lefebvre O, Wolf C, Limacher JM, Hutin P, Wendling C, LeMeur M, Basset P, Rio MC (1992) The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis. J Cell Biol 119: 997–1002

    Article  PubMed  CAS  Google Scholar 

  5. Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124: 619–626

    Article  PubMed  CAS  Google Scholar 

  6. Meredith JE Jr, Fazeli B, Schwartz MA (1993) The extracellular matrix as a cell survival factor. Mol Biol Cell 4: 953–961

    PubMed  CAS  Google Scholar 

  7. Yang C, Li SW, Helminen HJ, Khillan JS, Bao Y, Prockop DJ (1997) Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp Cell Res 235: 370–373

    Article  PubMed  CAS  Google Scholar 

  8. Schlessinger J (1997) Direct binding and activation of receptor tyrosine kinases by col-lagen. Cell 91: 869–872

    Article  PubMed  CAS  Google Scholar 

  9. Entwistle J, Hall CL, Turley EA (1996) HA receptors: regulators of signalling to the cytoskeleton. J Cell Biochem 61 (4): 69–577

    Article  Google Scholar 

  10. Hashimoto S, Setareh M, Ochs RL, Lotz M (1997) Fas/Fas ligand expression and induction of apoptosis in chondrocytes. Arthritis Rheum 40: 49–1755

    Article  Google Scholar 

  11. Zhang HY, Gharaee-Kermani M, Phan SH (1997) Regulation of lung fibroblast alpha-smooth muscle actin expression, contractile phenotype, and apoptosis by IL-1beta. J Immunol 158: 1392–1399

    PubMed  CAS  Google Scholar 

  12. Sarih M, Souvannavong V, Adam A (1993) Nitric oxide synthase induces macrophage death by apoptosis. Biochem Biophys Res Comm 191: 503–508

    CAS  Google Scholar 

  13. Fehsel K, Kroncke KD, Meyer KL, Huber H, Wahn V, Kolb-Bachofen V (1995) Nitric oxide induces apoptosis in mouse thymocytes. J Immunol 155: 2858–2865

    PubMed  CAS  Google Scholar 

  14. Loweth AC, Williams GT, Scarpello JH, Morgan NG (1997) Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15. FEBS Lett 400: 285–288

    Article  PubMed  CAS  Google Scholar 

  15. Tabuchi A, Oh E, Taoka A, Sakurai H, Tsuchiya T, Tsuda M (1996) Rapid attenuation of AP-1 transcriptional factors associated with nitric oxide (NO)-mediated neuronal cell death. J Biol Chem 271: 31061–31067

    Article  PubMed  CAS  Google Scholar 

  16. Nishio E, Fukushima K, Shiozaki M, Watanabe Y (1996) Nitric oxide donor SNAP induces apoptosis in smooth muscle cells through cGMP-independent mechanism. Biochem Biophys Res Comm 221: 163–168

    Article  PubMed  CAS  Google Scholar 

  17. Damoulis PD, Hauschka PV (1997) Nitric oxide acts in conjunction with proinflamma-tory cytokines to promote cell death in osteoblasts. J Bone Miner Res 12: 412–422

    Article  PubMed  CAS  Google Scholar 

  18. Ambs S, Hussain SP, Harris CC (1997) Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J 11: 443–448

    PubMed  CAS  Google Scholar 

  19. Messmer UK, Reed UK, Brune B (1996) Bc1–2 protects macrophages from nitric oxide-induced apoptosis. J Biol Chem 271: 20192–20197

    Article  PubMed  CAS  Google Scholar 

  20. Ho YS, Wang YJ, Lin JK (1996) Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells. Mol Carcinog 16: 20–31

    Article  PubMed  CAS  Google Scholar 

  21. Messmer UK, Brune B (1996) Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways. Biochem J 319: 299–305

    PubMed  CAS  Google Scholar 

  22. Melkova Z, Lee SB, Rodriguez D, Esteban M (1997) Bcl-2 prevents nitric oxide-mediated apoptosis and poly(ADP-ribose) polymerase cleavage. FEBS Lett 403: 273–278

    Article  PubMed  CAS  Google Scholar 

  23. Nitsch DD, Ghilardi N, Muhl H, Nitsch C, Brune B, Pfeilschifter J (1997) Apoptosis and expression of inducible nitric oxide synthase are mutually exclusive in renal mesangial cells. Am J Pathol 150: 889–900

    PubMed  CAS  Google Scholar 

  24. Lopez-Farre A, Sanchez de Miguel L, Caramelo C, Gomez-Macias J, Garcia R, Mosquera JR, de Frutos T, Millas I, Rivas F, Echezarreta G, Casado S (1997) Role of nitric oxide in autocrine control of growth and apoptosis of endothelial cells. Am J Physiol 272: H760—H768

    Google Scholar 

  25. Kim YM, de Vera ME, Watkins SC, Billiar TR (1997) Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem 272: 1402–1411

    Article  PubMed  CAS  Google Scholar 

  26. Blanco FJ, Ochs RL, Schwarz H, Lotz M (1995) Chondrocyte apoptosis induced by nitric oxide. Am J Pathol 146: 75–85

    PubMed  CAS  Google Scholar 

  27. Clancy RM, Abramson SB, Kohne C, Rediske J (1997) Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury. J Cell Physiol 172: 183–191

    Article  PubMed  CAS  Google Scholar 

  28. Frenkel SR, Clancy RM, Ricci JL, Di Cesare PE, Rediske JJ, Abramson SB (1996) Effects of nitric oxide on chondrocyte migration, adhesion and cytoskeletal assembly. Arthritis Rheum 39: 1905–1912

    Article  PubMed  CAS  Google Scholar 

  29. Baserga R, Resnicoff M, D’Ambrosio C, Valentinis B (1997) The role of the IGF-I receptor in apoptosis. Vitam Horm 53: 65–98

    Article  PubMed  CAS  Google Scholar 

  30. Clancy RM, Rediske J, Tang X, Nijher N, Frenkel S, Philips M, Abramson SB (1997) Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. J Clin Invest 100: 1789–1796

    Article  PubMed  CAS  Google Scholar 

  31. Vilar RE, Ghael D, Li M, Bhagat DD, Arrigo LM, Cowman MK, Dweck HS, Rosenfeld L (1997) Nitric oxide degradation of heparin and heparan sulphate. Biochem J 324: 473–479

    PubMed  CAS  Google Scholar 

  32. Evans CH, Watkins SC, Stefanovic-Racic M (1996) Nitric oxide and cartilage metabolism. Methods Enzymol 269: 75–88

    Article  PubMed  CAS  Google Scholar 

  33. Reed JC (1997) Cytochrome c: can’t live with it — can’t live without it. Cell 91: 559–562

    Article  PubMed  CAS  Google Scholar 

  34. Buckwalter JA, Mower D, Schafer J, Ungar R, Ginsberg B, Moore K (1985) Growthplate-chondrocyte profiles and their orientation. J Bone Joint Surg Am 676: 942–955

    Google Scholar 

  35. Hunziker EB, Schenk RK, Cruz-Orive LM (1987) Quantitation of chondrocyte performance in growth-plate cartilage during longitudinal bone growth. J Bone Joint Surg Am 69 (2): 162–173

    PubMed  CAS  Google Scholar 

  36. Lewinson D, Silbermann M (1992) Chondroclasts and endothelial cells collaborate in the process of cartilage resorption. Anat Rec 233: 504–514

    Article  PubMed  CAS  Google Scholar 

  37. Dearden LC, Bonucci E (1975) Filaments and granules in mitochondrial vacuoles in chondrocytes. Calcif Tissue Res 18: 173–194

    Article  PubMed  CAS  Google Scholar 

  38. Star AM, Iannotti JP, Brighton CT, Armstrong PF (1987) Cytosolic calcium concentration in bovine growth plate chondrocytes. J Orthop Res 5: 122–127

    Article  PubMed  CAS  Google Scholar 

  39. Kogaya Y, Furuhashi K (1988) Comparison of the calcium distribution pattern among several kinds of hard tissue forming cells of some living vertebrates. Scanning Microsc 2: 2029–2043

    PubMed  CAS  Google Scholar 

  40. Lee NH, Shapiro IM (1978) Cat+transport by chondrocyte mitochondria of the epiphyseal growth plate. J Membr Biol 41: 349–360

    Article  PubMed  CAS  Google Scholar 

  41. Stambough JL, Brighton CT, Iannotti JP, Storey BT (1984) Characterization of growth plate mitochondria. J Orthop Res: 235–246

    Google Scholar 

  42. Shapiro LM, Burke A, Lee NH (1976) Heterogeneity of chondrocyte mitochondria. A study of the Ca2+concentration and density banding characteristics of normal and rachitic cartilage. Biochim Biophys Acta 451: 583–591

    Article  PubMed  CAS  Google Scholar 

  43. Shapiro IM, Golub EE, Kakuta S, Hazelgrove J, Havery J, Chance B, Frasca P (1982) Initiation of endochondral calcification is related to changes in the redox state of hypertrophic chondrocytes. Science 217: 950–952

    Article  PubMed  CAS  Google Scholar 

  44. Wuthier RE, Chin JE, Hale JE, Register TC, Hale LV, Ishikawa Y (1985) Isolation and characterization of calcium-accumulating matrix vesicles from chondrocytes of chicken epiphyseal growth plate cartilage in primary culture. J Biol Chem 260: 15972–15979

    PubMed  CAS  Google Scholar 

  45. Landis WJ (1979) Application of electron probe X-ray microanalysis to calcification studies of bone and cartilage. Scan Electron Microsc 2: 555–570

    PubMed  Google Scholar 

  46. Ali SY (1976) Analysis of matrix vesicles and their role in the calcification of epiphyseal cartilage. Fed Proc 35: 135–142

    PubMed  CAS  Google Scholar 

  47. Ali SY, Sajdera SW, Anderson HC (1970) Isolation and characterization of calcifying matrix vesicles from epiphyseal cartilage. Proc Natl Acad Sci USA 67: 1513–1520

    Article  PubMed  CAS  Google Scholar 

  48. Wroblewski J, Wroblewski R, Mory C, Colliex C (1991) Elemental analysis and fine structure of mitochondrial granules in growth plate chondrocytes studied by electron energy loss spectroscopy and energy dispersive X-ray microanalysis. Scanning Microsc 5: 885–892

    PubMed  CAS  Google Scholar 

  49. Rudel T, Bokoch GM (1997) Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276: 1571–1574

    Article  PubMed  CAS  Google Scholar 

  50. Dijkgraaf LC, Liem RS, de Bont LG, Boering G (1995) Calcium pyrophosphate dihydrate crystal deposition disease: a review of the literature and a light and electron micro-scopic study of a case of the temporomandibular joint with numerous intracellular crystals in the chondrocytes. Osteoarthritis Cartilage 3: 35–45

    Article  PubMed  CAS  Google Scholar 

  51. Chai BF (1992) Relation of ultrastructural changes of articular cartilage and the arthroscopic classification in osteoarthritic knee. Chung Hua Wai Ko Tsa Chih 30: 18–20

    PubMed  CAS  Google Scholar 

  52. Gibson GJ, Kohler WJ, Schaffler MB (1995) Chondrocyte apoptosis in endochondral ossification of chick sterna. Dey Dyn 203: 468–476

    Article  CAS  Google Scholar 

  53. Farnum CE, Wilsman NJ (1987) Morphologic stages of the terminal hypertrophic chondrocyte of growth plate cartilage. Anat Rec 219: 221–232

    Article  PubMed  CAS  Google Scholar 

  54. Gibson G, Lin DL, Roque M (1997) Apoptosis of terminally differentiated chondrocytes in culture. Exp Cell Res 233: 372–382

    Article  PubMed  CAS  Google Scholar 

  55. Pfeifer A, Aszodi A, Seidler U, Ruth P, Hofmann F, Fassler R (1996) Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274: 2082–2086

    Article  PubMed  CAS  Google Scholar 

  56. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N et al (1995) Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81: 641–650

    Article  PubMed  CAS  Google Scholar 

  57. Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC (1993) Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75: 1273–1286

    Article  PubMed  CAS  Google Scholar 

  58. Archer CW (1994) Skeletal development and osteoarthritis. Ann Rheum Dis 53: 624–630

    Article  PubMed  CAS  Google Scholar 

  59. Silver FH, Glasgold AI (1995) Cartilage wound healing. An overview. Otolaryngol Clin North Am 28: 847–864

    PubMed  CAS  Google Scholar 

  60. Calandruccio RA, Gilmer WS (1962) Proliferation and repair of articular cartilage of immature animals. J Bone Joint Surgery Am 44: 431

    Google Scholar 

  61. Mankin HJ (1962) Localisation of tritiated thymidine incorporation in cartilage I Growth in immature cartilage. J Bone Joint Surgery Am 59: 1068

    Google Scholar 

  62. Bentley G, Greer RB 3rd (1971) Homotransplantation of isolated epiphyseal and articular cartilage chondrocytes into joint surfaces of rabbits. Nature 230: 385–388

    Article  PubMed  CAS  Google Scholar 

  63. Repo RU, Finlay JB (1977) Survival of articular cartilage after controlled impact. J Bone Joint Surgery Am 59: 1068–1076

    CAS  Google Scholar 

  64. Joseph J, Thomas G, Tynen J (1961) The reaction of the ear cartilage of the rabbit and guinea ig to trauma. J Anat 95: 564

    PubMed  CAS  Google Scholar 

  65. Walmsley R, Bruce J (1938) The early stages of replacement of the semilunar cartilages of the knee joints of rabbits after operative excision. J Anat 12: 260

    Google Scholar 

  66. Hashimoto S, Ochs RL, Komiya S, Lotz M (1998) The linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 41 (9): 1632–1638

    Article  PubMed  CAS  Google Scholar 

  67. Aigner T, Reichenberger E, Bertling W, Kirsch T, Stoss H, von der Mark K (1993) Type X collagen expression in osteoarthritic and rheumatoid articular cartilage. Virchows Arch B Cell Pathol Incl Mol Pathol 63: 205–211

    Article  PubMed  CAS  Google Scholar 

  68. Hoyland JA, Thomas JT, Donn R, Marriott A, Ayad S, Boot-Handford RP, Grant ME, Freemont AJ (1991) Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage. Bone Miner 15: 151–163

    Article  PubMed  CAS  Google Scholar 

  69. Walker GD, Fischer M, Gannon J, Thompson RC Jr, Oegema TR Jr (1995) Expression of type-X collagen in osteoarthritis. J Orthop Res 13: 4–12

    Article  PubMed  CAS  Google Scholar 

  70. Hashimoto S, Takahashi K, Amiel D, Coutts RD, Lotz M (1998) Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 41: 1266–1274

    Article  PubMed  CAS  Google Scholar 

  71. Anderson HC (1967) Electron microscopic studies of induced cartilage development and calcification. J Cell Biol 35: 81–101

    Article  PubMed  CAS  Google Scholar 

  72. Bonucci E (1967) Fine structure of early cartilage calcification. J Ultrastruct Res 20: 33–50

    Article  PubMed  CAS  Google Scholar 

  73. Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R, Lotz M (1998) Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci USA 95: 3094–3099

    Article  PubMed  CAS  Google Scholar 

  74. Aupeix K, Hugel B, Martin T, Bischoff P, Lill H, Pasquali JL, Freyssinet JM (1997) The significance of shed membrane particles during programmed cell death in vitro and in vivo in HIV-1 infection. J Clin Invest 99: 1546–1554

    Article  PubMed  CAS  Google Scholar 

  75. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR (1997) Immunosuppressive effects of apoptotic cells. Nature 390: 350–351

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Arthritis Research, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA

    Martin Lotz, Sanshiro Hashimoto, Robert Ochs & Klaus Kühn

Authors
  1. Martin Lotz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sanshiro Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Robert Ochs
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Klaus Kühn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Oncology Research, Smith Kline Beecham Pharmaceuticals, UW 2110 709 Swedeland Road, King of Prussia, PA, 19406, USA

    James D. Winkler (Assistant Director) (Assistant Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Basel AG

About this chapter

Cite this chapter

Lotz, M., Hashimoto, S., Ochs, R., Kühn, K. (1999). Chondrocyte apoptosis. In: Winkler, J.D. (eds) Apoptosis and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8741-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8741-0_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9752-5

  • Online ISBN: 978-3-0348-8741-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation