Abstract
It has been recognized for over a century that there are different forms of cell death. One form of cell death, necrosis, is usually the result of severe trauma and is a process that involves loss of membrane integrity and uncontrolled release of cellular contents, often giving rise to inflammatory responses. In contrast, the other form of cell death, apoptosis, is a more physiological process that occurs in a controlled manner and is generally non-inflammatory in nature. For this reason apoptosis is often referred to as programmed cell death. The name itself (apoptosis: Greek for “dropping off”, for example leaves from trees) implies a cell death that is part of a normal physiological process [1]. This introduction will review the general characteristics of apoptosis, its regulation and its role in physiology and disease, with the goal to directing the reader to current references and reviews of topics that are outside the scope of this book.
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References
Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239–257
Bright J, Khar A (1994) Apoptosis: Programmed cell death in health and disease. Biosci Rep14: 67–82
Bergamaschi G, Rosti V, Danova M, Lucotti C, Cazzola M (1994) Apoptosis: Biologi-cal and clinical aspects. Haematologica 79: 86–93
Stewart BW (1994) Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 86: 1286–1296
Golstein P (1997) Cell death: TRAIL and its receptors. Current Biology 7: R750–R753
Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME (1998) Apoptosis signal-ing by death receptors. Eur J Biochem 254: 439–459
Warzocha K, Salles G (1998) The tumor necrosis factor signaling complex: choosing a path toward cell death or cell proliferation. Leukemia & Lymphoma 29: 81–92
Yuan J, Horvitz HR (1990) The caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Devel Biol 138: 33–41
Barinaga M (1994) Cell suicide: by ICE, not fire. Science 263: 754–756
Yuan J (1997) Transducing signals of life and death. Curr Opin Cell Biol 9: 247–251
Allen RT, Cluck MW, Agrawal DK (1998) Mechanisms controlling cellular suicide: role of Bc1–2 and caspases. Cell Mol Life Sci 54: 427–445
Chinnaiyan AM, Orth K, O’Rourke K, Duan H, Poirier GG, Dixit VM (1996) Molecular ordering of the cell death pathway. Bc1–2 and Bcl-xL function upstream of the CED3-like apoptotic proteases. J Biol Chem 271: 4573–4576
Subramanian T, Tarodi B, Chinnadurai G (1995) Functional similarity between adenovirus E1B 19-kDa protein and proteins encoded by Bc1–2 proto-oncogene and Epstein-Barr virus BHRF1 gene. Curr Top Microbiol Immunol 199: 153–161
Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75: 641–652
Dixit VM (1996) Role of ICE-proteases in apoptosis. Adv Exp Med Biol 406: 113–117
Salvesen GS, Dixit VM (1997) Caspases: intracellular signaling by proteolysus. Cell 91: 443–446
Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281: 1312–1316
Thornberry NA, Rosen A, Nicholson DW (1997) Control of apoptosis by proteases. Adv Pharmacol 41: 155–177
Muzio M, Chinnaiyan AM, Kischkel FC, O’Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R et al (1996) FLICE, a novel FADD-homologous ICE/CED3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817–827
Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA 93: 7464–7469
Vaux DL (1997) CED-4 — The third horseman of apoptosis. Cell 90: 389–390
Reed JC (1997) Double identity for proteins of the Bcl-2 family. Nature 387: 773–776
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479–489
Hu Y, Benedict MA, Wu D, Inohara N, Nunez G (1998) Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA 95: 4386–4391
Green D, Kroemer G (1998) The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 8: 267–271
Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281: 1309–1312
Mignotte B, Vayssiere JL (1998) Mitochondria and apoptosis. Eur J Biochem 252: 1–15
Aggarwal BB, Higuchi M (1997) Role of ceramide in tumour necrosis factor-mediated apoptosis and nuclear factor-kappa B activation. Biochemical Society Transactions 25: 1166–1171
Haimovitz-Friedman A, Kolesnick RN, Fuks Z (1997) Ceramide signaling in apoptosis. British Medical Bulletin 53: 539–553
Hannun YA, Obeid LM (1997) Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol 407: 145–149
Kolesnick RN, Kronke M (1998) Regulation of ceramide production and apoptosis. Ann Rev Physiol 60: 643–665
Smyth MJ, Obeid LM, Hannun YA (1997) Ceramide: a novel lipid mediator of apoptosis. Adv Pharmacol 41: 133–154
Williams GT (1994) Apoptosis in the immune system. J Pathol 173: 1–4
Krammer PH, Behrmann I, Daniel P, Dhein J, Debatin KM (1994) Regulation of apoptosis in the immune system. Curr Opin Immunol 6: 279–289
Hetts SW (1998) To die or not to die: an overview of apoptosis and its role in disease. JAMA 279: 300–307
Kerr JFR, Winterford CM, Harmon BV (1994) Apoptosis: Its significance in cancer and cancer therapy. Cancer 73: 2013–2026
Ashwell JD, Berger NA, Cidlowski JA, Lane DP, Korsmeyer SJ (1994) Coming to terms with death: Apoptosis in cancer and immune development. Immunol Today 15: 147–151
Barr PJ, Tomei LD (1994) Apoptosis and its role in human disease. BioTechnology 12: 487–493
Patel T, Roberts LR, Jones BA, Gores GJ (1998) Dysregulation of apoptosis as a mechanism of liver disease: an overview. Semin Liver Dis 18: 105–114
Savitz SI, Rosenbaum DM (1998) Apoptosis in neurological disease. Neurosurgery 42: 555–572
Shivers BD, Boxer PA, Keane KM, Kupina NC, Lynch T, Schielke GP, Vartanian MG, Vasilakos JP (1998) Contribution of the ICE family to neurodegeneration. Ann NY Acad Sci 840: 59–64
Sabbah HN, Sharov VG (1998) Apoptosis in heart failure. Prog Cardiovas Dis 40: 549–562
Haunstetter A, Izumo S (1998) Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res 82: 1111–1129
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© 1999 Springer Basel AG
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Winkler, J.D. (1999). Introduction — Apoptosis in inflammatory cells and diseases. In: Winkler, J.D. (eds) Apoptosis and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8741-0_1
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DOI: https://doi.org/10.1007/978-3-0348-8741-0_1
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9752-5
Online ISBN: 978-3-0348-8741-0
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