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Combinatorial chemistry: Polymer supported synthesis of peptide and non-peptide libraries

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 53))

Summary

In recent years, combinatorial chemistry has emerged as a powerful tool for accelerating drug discovery. While industry is rapidly embracing the technology, researchers continue to develop novel library methods including resins, linkers, tagging and deconvolution techniques. Newer strategies involving computer-customized combinatorial libraries offer enormous potential for the design of more “focused” and “smart” chemical libraries with maximal diversity. In addition, miniaturized systems for synthesizing chemical libraries are also being developed, which has made it possible to carry out reactions at submicroliter volumes.

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Abbreviations

GC:

gas chromatography

ESMS:

electrospray mass spectrometry

ELISA:

enzyme linked immunoadsorbent assay

HPLC:

high pressure liquid chromatography

TG:

tentagel resin

PyBrOP:

bromo-tris-pyrrolidino-phsosphonium hexafluorophosphate

DCR:

divide couple and recombine

TFA:

triflouroacetic acid

NK:

neurokinin

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  1. Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, 226001, India

    Bijoy Kundu, Sanjay K. Khare & Shiva K. Rastogi

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Kundu, B., Khare, S.K., Rastogi, S.K. (1999). Combinatorial chemistry: Polymer supported synthesis of peptide and non-peptide libraries. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 53. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8735-9_3

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