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U-50,488 and the к receptor Part II: 1991–1998

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 53))

Summary

This review, Part 11, follows an earlier article, Part I, published in volume 52 of this series. Part 11 is a discussion of centrally and peripherally acting K agonists which can be considered analogs of U-50,488. Included also are three classes of K agonists which fall outside of the scope of the general structure of U-50,488. These are benzodiazepines, phenothiazines and diazobicyclonanones. The discussion also covers other pertinent topics including labelled ligands and sigma receptor.

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Abbreviations

SC:

subcutaneous

NMDA:

N-methyl-D-aspartate

nM:

nanomolar

IC50 :

inhibitory concentration50

LVD:

rabbit vas deferens essay

DUP:

DuPont

U:

Upjohn

ICI:

Imperial Chemical Industries

RP:

Rhone-Poulenc

i.v.:

intravenous

i.p.:

intraperitoneal

icv:

intracerebroventricular

EMD:

E. Merck Darmstadt

MAC:

mouse abdominal constriction test

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  1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556-5670, USA

    Jacob Szmuszkovicz

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  1. Steinweg 28, CH-4107, Ettingen, Switzerland

    Ernst Jucker

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Szmuszkovicz, J. (1999). U-50,488 and the к receptor Part II: 1991–1998. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 53. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8735-9_1

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