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Present status of hepatoprotectants

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 52))

Summary

Perpetual exposure of liver to xenobiotics and therapeutic agents leads to toxic manifestations of a complex and diverse nature. Not a single curative therapeutic agent has been found so far which could provide lasting remedy to patients suffering from hepatic disorders. In fact, the remedies available in the modern system of medicine provide only symptomatic relief without any significant changes on the disease process. Moreover, their use is associated with severe side effects and chances of relapses. Except some natural products claimed to be effective, no safe synthetic product is yet available for the management of hepatic disorders. Lack of effective, least toxic and curative hepatoprotectants made the task difficult to discover newer drugs. This review is an attempt to provide an overall view of the development of synthetic and natural products as hepatoprotective agents.

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Abbreviations

ALT:

alanine aminotransferase

AST:

aspartate aminotransferase

CDCA:

chenodeoxycholic acid

CoA:

coenzyme A

D-GaIN:

D-galactosamine

GSH:

glutathione

HBV:

hepatitis B virus

HBeAG:

hepatitis B e antigen

HMG-CoA:

3-hydoxy-3-methylglutaryl coenzyme A

i.p.:

intra peritoneal

LAK:

lymphokine activated killer

LCAT:

lecithin cholesterol acyl transferase

LDH:

lactic dehydrogenase

LDL:

low density lipoprotein

LPS:

lipopolysaccharide

NAD:

nicotinamide adenine dinucleotide

NADH:

nicotinamide adenine dinucleotide phosphate

NPCS:

nonparenchymal

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  1. Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India

    Vishnu Ji Ram & Atul Goel

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  1. Vishnu Ji Ram
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  2. Atul Goel
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  1. Steinweg 28, CH-4107, Ettingen, Switzerland

    Ernst Jucker

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Ji Ram, V., Goel, A. (1999). Present status of hepatoprotectants. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 52. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8730-4_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8730-4_2

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