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Recent advances in immunosuppressants

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 52))

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Summary

In recent years, a large number of structurally diverse immunosuppressants have been discovered that are effective for the treatment of organ transplantation. Some of them are undergoing clinical trials and may soon enter into routine clinical practice. These compounds are either chemical entities obtained from natural sources/synthetic means or biomaterials such as monoclonal antibodies/gene products/proteins. They have been found to interfere at different stages of T cell activation and proliferation, and can be identified as inhibitors of nucleotide synthesis, growth factor signal transduction and differentiation. Newer strategies involving combination of new agents with traditional immunosuppressants, monoclonal antibodies and gene therapy offer enormous potential, not only for the investigation of mechanisms pertaining to graft rejection, but also for its therapeutic prevention.

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Abbreviations

CTL:

Dcytotoxic T lymphocytes

CsA:

cyclosporin A

GVHD:

graft versus host disease

PHA:

phytohemagglutinin

DHODH:

dihydroorotate dehydrogenase

HPLC:

high performance liquid chromatography

PKM:

pokweed mitogen

MLR:

mixed lymphocyte reaction

DSG:

15, deoxyspergualin

MHC:

major histocompatibility complex

IFN:

interferon

moab:

monoclonal antibodies

rHu:

recombinant human

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Kundu, B., Khare, S.K. (1999). Recent advances in immunosuppressants. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 52. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8730-4_1

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