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TNFα converting enzyme

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Metalloproteinases as Targets for Anti-Inflammatory Drugs

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Tumor necrosis factor a (TNFα) is a pleiotropic cytokine that mediates inflammatory and apoptotic processes by binding to two different receptors and thereby initiating complex signaling transduction pathways [1]. While TNFa has been studied since the earlier part of this century, the purification and cloning of this protein in 1985 [2 – 5] precipitated a decade of intensive research. These efforts demonstrated the cross-disciplinary significance of this molecule and gave insight into the signaling pathways that initiated TNFα transcription, the unique control of its translation and the TNF receptors that bind the secreted, 17 kDa molecule. These receptors reside on cells of nearly every tissue and, in turn, transduce the signals that result in changes in cell behavior.

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References

  1. B Beutler (ed) (1994) Tumor necrosis factors: The molecules and their emerging role in medicine. Raven Press, New York

    Google Scholar 

  2. Haranaka K, Carswell EA, Williamson BD, Prendergast JS, Satomi N, Old LJ (1986) Proc Natl Acad Sci USA 83: 3949–3953

    Article  PubMed  CAS  Google Scholar 

  3. Aggarwal BB, Kohr WJ, Hass PE, Moffat B, Spencer SA, Henzel William J, Bringman TS, Nedwin GE, Goeddel DV, Harkins RN (1985) J Biol Chem 260(4): 2345–2354

    PubMed  CAS  Google Scholar 

  4. Pennica D, Hayflick JS, Bringman TS, Palladino MA, Goeddel DV (1985) Proc Natl Acad Sci USA 82(18): 6060–6064

    Article  PubMed  CAS  Google Scholar 

  5. Wang AM, Creasey AA, Ladner MB, Lin LS, Strickler J, Van Arsdell JN, Yamamoto R, Mark DF (1985) Science 228(4696): 149–154

    Article  PubMed  CAS  Google Scholar 

  6. Utsumi T, Levitan A, Hung M, Klostergaard J (1993) J Biol Chem 268: 9511–9516

    PubMed  CAS  Google Scholar 

  7. Kriegler M, Perez C, DeFay AI, Lu SD (1988) Cell 53: 45–53

    Article  PubMed  CAS  Google Scholar 

  8. Perez C, Albert I, DeFay K, Zachariades N, Gooding L, Kriegler M (1990) Cell 63(2): 251–258

    Article  PubMed  CAS  Google Scholar 

  9. McGeehan GM, Becherer JD, Bast RC Jr, Boyer CM, Champion B, Connolly KM, Con-way JG, Furdon P, Karp S, Kidao S et al (1994) Nature 370: 558–561

    Article  PubMed  CAS  Google Scholar 

  10. Gearing AJ, Beckett P, Christodoulou M, Churchill M, Clements J, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL et al (1994) Nature 370: 555–557

    Article  PubMed  CAS  Google Scholar 

  11. Mohler KM, Sleath PR, Fitzner JN, Cerretti DP, Alderson M, Kerwar SS, Torrance DS, Otten-Evans C, Greenstreet I, Weerawarna K et al (1994) Nature 370: 218–220

    Article  PubMed  CAS  Google Scholar 

  12. Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D et al (1997) Nature 385: 733–736}.

    Article  PubMed  CAS  Google Scholar 

  13. Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolf son MF, Castner BJ, Stocking KL, Reddy P, Srinivasan S et al (1997) Nature 385: 729–733

    Article  PubMed  CAS  Google Scholar 

  14. Howard L, Lu X, Mitchell S, Griffiths S, Glynn P (1996) Biochem J 317: 45–50

    PubMed  CAS  Google Scholar 

  15. Yagami-Hiromasa T, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawa-Seharar A (1995) Nature 377: 652–656

    Article  PubMed  CAS  Google Scholar 

  16. Kratzschmar J, Lum L, Blobel CP (1996) / Biol Chem 271: 4593–4596

    Article  CAS  Google Scholar 

  17. Blobel CP, Wolfsberg TG, Turck CW, Myles DG, Primakoff P, White JM (1992) Nature 356: 248–252

    Article  PubMed  CAS  Google Scholar 

  18. Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (1993) Nature Genet 5, 151–157

    Article  PubMed  CAS  Google Scholar 

  19. Yoshida S et al (1990) International Immunology 26: 585–591

    Article  Google Scholar 

  20. Perry ACF, Jones R, Barker PJ, Hall L (1992) Biochem J 286: 671–675

    PubMed  CAS  Google Scholar 

  21. Gomis-Ruth FX, Kress LF, Kellermann J, Mayr I, Lee X, Huber R, Bode W (1994) / Mol Biol 239: 513–544

    Article  CAS  Google Scholar 

  22. Grams F, Huber R, Kress LF, Moroder L, Bode W (1993) FEBS Lett 335: 76–80

    Article  PubMed  CAS  Google Scholar 

  23. Hooper NM (1994) FEBS Letts 354: 1–6

    Article  CAS  Google Scholar 

  24. Zhou Q, Dangelmaier C, Smith JB (1996) Biochem Biophys Res Comm 219(3): 720–726

    Article  PubMed  CAS  Google Scholar 

  25. Chantry A, Gregson NA, Glynn P (1989) J Biol Chem 264: 21603–21697

    PubMed  CAS  Google Scholar 

  26. Rooke J, Pan D, Xu T, Rubin GM (1996) Science 273: 1227–1231

    Article  PubMed  CAS  Google Scholar 

  27. Pan D, Rubin GM (1997) Cell 90: 271–280

    Article  PubMed  CAS  Google Scholar 

  28. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (1997) Cell 90: 281–291

    Article  PubMed  CAS  Google Scholar 

  29. Lunn CA, Fan X, Dalie B, Miller K, Zavodny PJ, Naurla SK, Lundell D (1997) FEBS Letts 400: 333–335

    Article  CAS  Google Scholar 

  30. Rosendahl MS et al (1997) / j Biol Chem 272. 24588–24593

    Article  PubMed  CAS  Google Scholar 

  31. O’Byrne EM, Parker DT, Roberts ED, Goldberg RL, MacPherson LJ, Blancuzzi V, Wilson D, Singh HN, Ludewig R, Ganu VS (1995) Inflammation Res 44(Suppl 2), S117–S118

    Article  CAS  Google Scholar 

  32. Arribas J, Coodly L, Vollmer P, Kishimoto TK, Rose-John S, Massague J (1996) J Biol Chem 271: 11376–11382

    Article  PubMed  CAS  Google Scholar 

  33. Bennett TA, Lynam EB, Sklar LA, Rogelj S (1996) J Immunol 156: 3093–3097

    PubMed  CAS  Google Scholar 

  34. Mullberg J, Durie FH, Otten-Evans C, Alderson MR, Rose-John S, Cosman D, Black RA, Mohler KM (1995) J Immunol 155: 5198–5205

    PubMed  CAS  Google Scholar 

  35. Williams LM, Gibbons DL, Gearing A, Maini RN, Feldmann F, Brennan FM (1996) J Clin Invest 97: 2833–2841

    Article  PubMed  CAS  Google Scholar 

  36. Crowe PD, Walter BN, Mohler KM, Otten-Ewans C, Black RA, Ware CF (1995) J Exp Med 181: 1205

    Article  PubMed  CAS  Google Scholar 

  37. Lambert MH (in press) In: PS Charifson (ed): Computer-assisted modeling in molecular pharmacology. Marcel Dekker, New York

    Google Scholar 

  38. Feng D-F, Doolittle RF (1987) J Mol Evol 25: 351–360

    Article  PubMed  CAS  Google Scholar 

  39. Lovejoy B, Cleasby A, Hassell AM, Longley K, Luther MA, Weigl D, McGeehan G, McElroy AB, Drewry D, Lambert MH, Jordan SR (1994) Science 263: 375–377

    Article  PubMed  CAS  Google Scholar 

  40. Lambert MH (1997) In: PS Charifson (ed): Practical application of computer-aided drug design. Marcel Dekker, New York, 243–303

    Google Scholar 

  41. Senn H, Klaus W (1993) J Mol Biol 232: 907–925

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Glaxo Wellcome Inc, 5 Moore Dr., Research Triangle Park, NC, 27709, USA

    Marcia Moss, J. David Becherer, Marcos Milla, Gregory Pahel, Mill Lambert, Rob Andrews, Stephen Frye, Curt Haffner, David Cowan, Patrick Maloney, Eric P. Dixon, Marilyn Jansen, Justin Mitchell, Tony Leesnitzer, Janet Warner, James Conway, D. Mark Bickett, Mike Bird, Richard Priest, John Reinhard & Peiyuan Lin

  2. Division of Neurology, Duke Medical Center, P.O. Box 2900, Durham, NC, 27710, USA

    Michael P. Vitek

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  1. Marcia Moss
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  5. Mill Lambert
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  10. Patrick Maloney
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  11. Eric P. Dixon
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  14. Justin Mitchell
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  15. Tony Leesnitzer
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  16. Janet Warner
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  17. James Conway
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  18. D. Mark Bickett
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  19. Mike Bird
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Editor information

Editors and Affiliations

  1. Roche Discovery Welwyn, Roche Products Ltd., 40 Broadwater Road, Welwyn Garden City, GB-Herfordshire, AL7 3AY, UK

    Kevin M. K. Bottomley , David Bradshaw  & John S. Nixon ,  & 

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© 1999 Springer Basel AG

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Moss, M. et al. (1999). TNFα converting enzyme. In: Bottomley, K.M.K., Bradshaw, D., Nixon, J.S. (eds) Metalloproteinases as Targets for Anti-Inflammatory Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8666-6_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8666-6_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9724-2

  • Online ISBN: 978-3-0348-8666-6

  • eBook Packages: Springer Book Archive

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